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Detection of Runs of Homozygosity from Whole Exome Sequencing Data: State of the Art and Perspectives for Clinical, Population and Epidemiological Studies
Exome sequencing Runs of homozygosity Homozygosity mapping
2015/5/5
Runs of homozygosity (ROH) are sizeable stretches of homozygous genotypes at consecutive polymorphic DNA marker positions, traditionally captured by means of genome-wide single nucleotide polymorphism...
H3M2:detection of runs of homozygosity from whole-exome sequencing data
H3M2 runs of homozygosity whole-exome sequencing data
2015/5/5
Motivation: Runs of homozygosity (ROH) are sizable chromosomal stretches of homozygous genotypes, ranging in length from tens of kilobases to megabases. ROHs can be relevant for population and medical...