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儿童医学中心科研团队揭示人类细胞中NEIL3和FA/BRCA途径在DNA链间交联损伤修复中的协同机制（图）
儿童医学中心科研团队 人类细胞 NEIL3 FA/BRCA DNA链间 交联损伤修复 协同机制
2020/4/7
近期，国家儿童医学中心（上海）、上海交通大学医学院附属上海儿童医学中心王剑研究员、陈静教授领衔的合作团队与美国哈佛医学院附属丹娜法伯癌症研究中心联合于国际权威杂志Nucleic Acids Research发表了文章，该研究首次在人类细胞中明确了NEIL3基因对DNA-ICLs损伤的重要修复作用，并进一步详尽阐述了NEIL3和FA/BRCA途径在psoralen-ICL修复中的协同作用及其分子调控...
基因组DNA存储着生物体赖以生存和繁衍的遗传信息，维护DNA分子的完整性对细胞发挥正常功能至关重要。外源环境因素（如辐射）和生物体内源因素（如代谢产物）经常会导致DNA结构发生变化，造成DNA损伤。若DNA损伤不能被及时修复，细胞将经历细胞周期停滞、衰老或程序性细胞死亡，就会对机体造成威胁，甚至会导致疾病的发生。生物体内也存在一系列DNA损伤修复机制，以应对各种类型的DNA损伤。DNA修复过程涉及...
3D-MODELING OF VEGETATION FROM LIDAR POINT CLOUDS AND ASSESSMENT OF ITS IMPACT ON FAÇADE SOLAR IRRADIATION
LiDAR solar potential solar irradiation vegetation convex hull individual tree crown detection (ITCD)
2016/10/14
The presence of vegetation can significantly affect the solar irradiation received on building surfaces. Due to the complex shape and seasonal variability of vegetation geometry, this topic has gained...
GESTALT GROUPING ON FAÇADE TEXTURES FROM IR IMAGE SEQUENCES: COMPARING DIFFERENT PRODUCTION SYSTEMS
Faç ade recognition thermal imagery production systems
2014/4/28
The façades of buildings are almost always organized according to Gestalt principles such as good continuation, repetition in similarity, or symmetry etc. Coding such principles in production sys...
Bartington MS2和Kappabridge MFK1-FA不同频率的磁化率在黄土、红粘土和湖相沉积物中的应用
频率磁化率 Bartington MS2和Kappabridge MFK1-FA磁化率仪 细颗粒亚铁磁性矿物
2013/11/5
通过Bartington MS2 和Kappabridge MFK1-FA两种仪器对黄土-古土壤、红粘土和湖相沉积物样品进行了5个频率的磁化率测试，并计算得到了4个频率磁化率。通过对比分析不同类型样品磁化率-频率变化曲线可知，当样品中细颗粒磁性矿物含量较高时，磁化率在较低频率即可达到峰值，而当样品中细颗粒磁性矿物含量较低时，磁化率在较高频率时才能达到峰值。因此，在黄土-古土壤等样品的应用中，成壤作...
A new algorithm for computing the multivariate Faà di Bruno's formula
multivariate composite function Fa`a di Bruno’s formula multivariate cumulant
2011/3/1
A new algorithm for computing the multivariate Fa`a di Bruno’s formula is provided.We use a symbolic approach based on the classical umbral calculus that turns the computation of the multivariate Fa`a...
A new algorithm for computing the multivariate Faà di Bruno's formula
algorithm computing multivariate Faà di Bruno's formula
2011/1/4
A new algorithm for computing the multivariate Fa\`a di Bruno's formula is provided. We use a symbolic approach based on the classical umbral calculus that turns the computation of the multivariate Fa...
Effects of Conjugated Linoleic Acid and Stearic Acid on Apoptosis of the INS-1 β-cells and Pancreatic Islets Isolated from Zucker Obese (fa/fa) Rats
INS-1 b-cells Pancreatic Islets CLA Apoptosis
2016/4/13
To determine whether dietary fatty acids affect pancreatic b-cell function, the INS-1 b-cells and the pancreatic islets isolated from Zucker obese (fa/fa) rats were cultured with stearic acid and conj...