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Synthesis and Biological Activity of Allosteric Modulators of GABAB Receptors. Part 4. Synthesis of Potentially Fluorescent Acridines and Conformationally Restricted N-(arylpropyl)-1-arylethylamines
Fendiline analogues acridines acridones aminotetralins aminoindanes GABA
2010/4/15
A series of 8 new derivatives of fendiline was prepared for evaluation as allosteric modulators of GABAB receptors: 4 based on acridine and 4 with restricted distance between the 2 aryl moieties.
Synthesis, Spectroscopic and Biological Investigation of Cyclic Octapeptide: Cherimolacyclopeptide G
Cyclic octapeptide cherimolacyclopeptide G antibacterial activity antifungal activity anthelmintic activity cytotoxicity
2010/4/16
A natural cyclic octapeptide cherimolacyclopeptide G (8) was synthesized by coupling of tetrapeptide units Boc-Gly-Ala-Val-Pro-OMe (5) and Boc-Ile-Tyr-Ala-Pro-OMe (6) after proper deprotection at carb...
Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation
Sonogashira reaction 4-ipomeanol cytotoxic activity MTT assay
2010/4/19
The thiophene analogue of (\pm)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisa...
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications
Derivatives Synthesis Spectroscopic Characterization Biological Applications
2010/4/20
Some new di- and tri-organotin(IV) derivatives of 4 different non-steroidal anti-inflammatory drugs (NSAIDs) with the general formulae R2SnL2 and R3SnL (where R = n-C8H17 and C6H5CH2) and L = 2-[(2,3-...
Secondary Metabolites of Phlomis viscosa and Their Biological Activities
Phlomis viscosa iridoids phenylethanoid glycosides lignan glucosides 8-O-4'-oxylignan neolignan glucosides biological activity
2010/4/20
Further phytochemical studies on the aerial parts of Phlomis viscosa (Lamiaceae) led to the isolation of 24 compounds: 3 iridoid glycosides, 10 phenylethanoid glycosides, a megastigmane glycoside and ...
1H, 13C, 119Sn NMR, Mass, Mössbauer and Biological Studies of Tri-,Di- and Chlorodiorganotin(IV) Carboxylates
1H 13C 119Sn NMR Mass Mö ssbauer Biological Studies
2010/4/21
The reaction of 2-[(2,3-dimethylphenyl)amino]benzoic acid (HL) with tri- and diorganotin(IV) chlorides yielded complexes of the type R3SnL and R2SnL2 (R = n-C4H9, C6H5, C6H5CH2, n-C8H17). The compound...
Synthesis, Characterization and Biological Applications of Organotin(IV) Derivatives of 2-(2-Fluoro-4-biphenyl)propanoic Acid
Synthesis Characterization Biological 2-(2-Fluoro-4-biphenyl)propanoic Acid
2010/4/21
A series of organotin(IV) derivatives with the general formula R4 - nSnLn (where n = 1 or 2, R = Me, Et, n-Bu, Ph and L = 2-(2-fluoro-4-biphenyl)propanoate) have been synthesized and characterized by ...