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Why might the finding of a new genetic association with inflammatory bowel disease be of potential value in disease control?
new genetic association inflammatory bowel disease potential value disease control
2018/11/20
Inflammatory bowel disease (IBD) has long been recognized as an exaggerated inflammatory response to common antigenic stimuli in the gut. Ulcerative colitis (UC) (1) and Crohn disease (CD) (2) are the...
Association of TCN2 rs1801198 c.776G>C polymorphism with markers of one-carbon metabolism and related diseases: a systematic review and meta-analysis of genetic association studies
cobalamin c.776G>C genetic association studies
2018/11/20
Background: Vitamin B-12 (cobalamin) deficiency may produce severe neurologic and hematologic manifestations. Approximately 20–25% of circulating cobalamin binds to transcobalamin 2 (TCN2), which is r...
Genetic Association of the Porcine C9 Complement Component with Hemolytic Complement Activity
Porcine C9 Polymorphisms Hemolytic Complement Activity
2016/5/18
The complement system is a part of the natural immune regulation mechanism against invading pathogens. Complement activation from three different pathways (classical, lectin, and alternative) leads to...
Population Structure and Cryptic Relatedness in Genetic Association Studies
Population Structure Cryptic Relatedness Genetic Association Studies
2010/11/16
We review the problem of confounding in genetic association studies, which arises principally because of population structure and cryptic relatedness. Many treatments of the problem consider only a si...