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Coenzyme Q10 prevents hepatic fibrosis, inflammation, and oxidative stress in a male rat model of poor maternal nutrition and accelerated postnatal growth
developmental programming liver disease coenzyme Q low birth weight accelerated postnatal growth
2018/11/28
Background: It is well established that low birth weight and accelerated postnatal growth increase the risk of liver dysfunction in later life. However, molecular mechanisms underlying such developmen...
Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: accumulation in Purkinje cells of the cerebellum
prostaglandin E2 EP1 prostanoid receptors rat brain cerebellum Purkinje cells cyclooxygenase neuroimmunology
2015/8/3
Prostaglandin E2 (PGE2), is a major prostanoid produced by the activity of cyclooxygenases (COX) in response to various physiological and pathological stimuli. PGE2 exerts its effects by activating fo...
Effect of Lactobacillus plantarum LS/07 in combination with flaxseed oil on the microflora, enzymatic activity, and histological changes in the development of chemically induced precancerous growth in the rat colon
probiotic PUFA 1.2-DMH
2015/7/2
This experimental study showed the effect of L. plantarum LS/07 on the changes in total counts of coliform bacteria, enzymatic activities, cytokine and histological changes in the colonic mucosa, chem...
Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level
PPARα SREBP-2 Insig-1
2015/7/2
A hypothesis that eicosapentaenoic acid + docosahexaenoic acid (EPA+DHA) lower plasma cholesterol via increased expression of the Insig-1 gene with ensuing decrease of expression of genes coding for 3...
Impact of cadmium on the level of hepatic metallothioneins, essential elements, and selected enzymes in the experimental rat model
metal intoxication liver blood plasma detoxification Rattus norvegicus L.
2015/7/2
The response of different strains of laboratory rats (Rattus norvegicus L.) on both acute (via intraperitoneal injection) and chronic (via drinking water and/or diet) cadmium intoxication was investig...
Maternal thyroid hormone regulates gene expression in the fetal rat brain
Clinical thyroid hormone the fetus gene
2014/12/11
Recent clinical evidence indicates that thyroid hormone plays an essential role in fetal brain development. However, the mechanism by which thyroid hormone affects development has been largely unexplo...
The action of T- and CS -syndrome pyrethroids on voltage-sensitive calcium channels in rat brain
Nerve terminals deltamethrin chrysanthemum ester calcium influx and neurotransmitter release fluorescence assay calcium influx of deltamethrin stimulation
2014/12/11
Isolated presynaptic nerve terminals (synaptosomes) prepared from rat brain were used to evaluate the action of a classic T-syndrome (cismethrin) and CS-syndrome (deltamethrin) pyrethroid on voltage-s...
TRAF-interacting protein, an inhibitor of the canonical nuclear factor-kappaB pathway, plays a key role in the estradiol -dependent apoptosis of the dual-phenotype gamma amino butyric acid/glutamate neurons in the anteroventral periventricular nucleus of the male rat
Mediated estradiol LH surge neurons male AVPV E2 - mediated cell death neurons
2014/12/11
The anteroventral periventricular nucleus (AVPV) of the preoptic area mediates the positive feedback effects of estradiol (E2) on LH surge in rats. Consistent with their role in female reproduction, t...
Red Deer Antler Extract Accelerates Hair Growth by Stimulating Expression of Insulin-like Growth Factor I in Full-thickness Wound Healing Rat Model
Hair Growth Wound Healing Growth Factors IGF-I Wingless-type MMTV Integration Site Family (Wnt)
2016/5/10
In order to investigate and evaluate the effects of red deer antlers on hair growth in the full-thickness wound healing model, Sprague-Dawley rats were given incision wounds through the full thickness...
Strong surround antagonism in the dLGN of the awake rat
thalamus whitening decorrelation redundancy reduction rodent vision
2012/5/2
Classical center-surround antagonism in the early visual system is thought to serve important functions such as enhancing edge detection and increasing sparseness. The relative strength of the center ...
Effects of Dietary Protein and Threonine Supply on In vitro Liver Threonine Dehydrogenase Activity and Threonine Efficiency in Rat and Chicken
Threonine Oxidation Threonine Efficiency Threonine Dehydrogenase Liver of Rat and Chicken
2016/5/9
This study was conducted to assess the relation between threonine (Thr) oxidation rate and threonine efficiency on rat and chicken fed with graded levels of protein and threonine. The increase in thre...
Differential afferent sensitivity to mucosal lipopolysaccharide from Salmonella typhimurium and Escherichia coli in the rat jejunum
5-HT afferent nerve enteritis hypersensitivity mesenteric
2014/5/16
Postinfectious irritable bowel syndrome may develop subsequent to acute bacterial enteritis. We therefore hypothesized that intestinal afferents may develop hypersensitivity upon exposure to luminal l...
Effect of Thyroid Hormone on the Gene Expression of Myostatin in Rat Skeletal Muscle
Thyroid Hormone Skeletal Muscle Hyperthyroidism Hypothyroidism Myostatin Expression
2016/4/29
Modification of thyroid hormone levels has a profound effect on skeletal muscle differentiation, predominantly through direct regulation involving thyroid hormone receptors. Nevertheless, little is kn...
Sterility and Abortive Effects of the Commercial Neem (Azadirachta indica A. Juss.) Extract NeemAzal- T/S® on Female Rat (Rattus norvegicus)
Neem extract sterility abortion histopathology hematology progesterone
2010/3/25
Azadirachta indica A.Juss. (neem) is an important plant species with reported reversible infertility and spontaneous abortive properties. NeemAzal-T/S® 1% was fed to 3 experimental groups by stoma...
Effects of Red Deer Antlers on Cutaneous Wound Healing in Full-thickness Rat Models
Deer Antler Full-thickness Wound Healing IGF-I TGF-??keyword6=EGF
2016/4/27
The process of wound repair involves an ordered sequence of events such as overlapping biochemical and cellular events that, in the best of circumstances, result in the restoration of both the structu...