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近日,华西基础医学与法医学院刘肖珩教授团队在Bone Research发表原创研究论文,证实了基质囊泡来源的AnxA5在骨重塑中的重要作用,阐明了AnxA5通过促进基质囊泡与I型胶原的黏附,诱导骨前体细胞发生自噬和加速矿化预防骨丢失的新机制,为骨质疏松症的防治提供新策略。
Background: Little is known about bone mineral density (BMD) during pregnancy. Advances in technology with lower radiation emissions by dual-energy X-ray absorptiometry instruments now permit the safe...
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therap...
Background: Female age-related estrogen deficiency increases the risk of osteoporosis, which can be effectively treated with the use of hormone replacement therapy. However, hormone replacement therap...
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
Background: Age-related estrogen deficiency leads to accelerated bone resorption. There is evidence that, through selective estrogen receptor modulation, isoflavones may exert beneficial effects again...
The systematic review of dietary protein and bone health and falls in the current issue of the Journal by Shams-White et al. (1) is thorough and timely. Their key findings are that dietary protein int...
Background: Considerable attention has recently focused on dietary protein’s role in the mature skeleton, prompted partly by an interest in nonpharmacologic approaches to maintain skeletal health in a...
Background: Bone mineral content (BMC) and bone mineral density (BMD) are positively correlated with dietary protein intakes, which account for 1–8% of BMC and BMD variances. However, the relation bet...
Background: The mechanism and clinical significance of low circulating 25-hydroxyvitamin D [25(OH)D] in obese people are unknown. Low total 25(OH)D may be due to low vitamin D–binding proteins (DBPs) ...
Background: Weight loss (WL) negatively affects bone mineral density (BMD) in older populations and has specifically been shown in women.
Background: The storage of adipose tissue in ectopic compartments is a hallmark attribute linking greater body mass index (BMI) with cardiometabolic diseases. Despite ample evidence to confirm that in...
Background: The storage of adipose tissue in ectopic compartments is a hallmark attribute linking greater body mass index (BMI) with cardiometabolic diseases. Despite ample evidence to confirm that in...
MIT chemical engineers have devised a new implantable tissue scaffold coated with bone growth factors that are released slowly over a few weeks. When applied to bone injuries or defects, this coated s...
Physical activity (PA) enhances bone structural strength at the proximal femur in adolescence, but whether these benefits are maintained into early adulthood remains unknown. The purpose of this study...

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