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Background: Stunting affects ~25% of children <5 y of age and is associated with impaired cognitive and motor development and increased morbidity and mortality. The pathogenesis of stunting is poorly ...
Background: Increased omega-3 (n–3) fatty acid consumption is reported to benefit patients with metabolic syndrome, possibly due to improved adipose tissue function.
Background: Obesity and associated metabolic disorders are related to impairments of the intestinal barrier. Objective: We examined lactulose:mannitol (Lac:Man) permeability in obese individuals with...
The cecum and colon are an integral, but somewhat neglected, part of the human digestive system. This digestion is affected not by human enzymes but by the microbiota that degrade undigested dietary c...
Background: Plasma lysophospholipids have emerged as signaling molecules with important effects on inflammation, insulin resistance, and fatty liver disease, each of which is linked closely to obesity...
Background: Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental cha...
The vast majority of infant formulas in the United States contain the long-chain polyunsaturated fatty acids (PUFAs) docosahexaenoic acid (22:6n–3) and arachidonic acid (20:4n–6), which were first per...
Background: Circulating trans fatty acids (TFAs), which cannot be synthesized by humans, are linked to adverse health outcomes. Although TFAs are obtained from diet, little is known about subsequent i...
Background: Biochemical evidence has linked the coordinate control of fatty acid (FA) synthesis with the activity of stearoyl-CoA desaturase-1 (SCD1). The ratio of 16:1n–7 to 16:0 [SCD1(16)] in plasma...
Animal and human studies have documented several effects of different dietary and tissue concentrations of long-chain polyunsaturated fatty acids (LCPUFAs) on retinal function and vision. The enhan...
Much interest has been expressed about the long-chain polyunsaturated fatty acid (LCPUFA) requirements of both preterm and term infants, whereas relatively little attention has been given to the LC...
In the past 2 decades, views about dietary n23 fatty acids have moved from speculation about their functions to solid evidence that they are not only essential nutrients but also may favorably modu...
In the United States, intake of n23 fatty acids is <1.6 g/d (<0.7% of energy), of which 1.4 g is a-linolenic acid (ALA; 18:3) and 0.1–0.2 g is eicosapentaenoic acid (EPA; 20:5) and docosahexaenoic ...

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