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Mechanisms of recruitment of the CTD phosphatase Rtr1 to RNA polymerase II
Rtr1 RNA polymerase II transcription
2015/5/25
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit Rpb1 must exist in a hypophosphorylated state prior to forming a competent transcription initiation complex. However, during trans...
Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
Phosphatase of Regenerating Liver PTEN Mouse Models
2015/5/25
The addition and removal of phosphate groups is a key regulatory mechanism for many cellular processes. The balance between phosphorylation and dephosphorylation is delicate and must be maintained in ...
The role of the CTD phosphatase Rrt1 and post-translational modifications in regulation of RNA polymerase II
CTD phosphatase Rtr1 MuDPIT AP-MS
2015/5/25
RNA polymerase II (RNAPII) is regulated by multiple modifications to the C-terminal domain (CTD) of the largest subunit, Rpb1. This study has focused on the relationship between hyperphosphorylation o...
Expression and Function of the PRL Family of Protein Tyrosine Phosphatase
PRL phosphatase PTP4A DSP cancer
2015/5/22
The PRL family of enzymes constitutes a unique class of protein tyrosine phosphatase, consisting of three highly homologous members (PRL-1, PRL-2, and PRL-3). Family member PRL-3 is highly expressed i...