搜索结果: 1-15 共查到“医学 ATP”相关记录103条 . 查询时间(0.093 秒)
柏林课题组与合作者揭示真菌质膜质子ATP酶的底物转运机制(图)
北京大学基础医学院 真菌质膜质子 真菌药物
2023/8/14
2021年11月8日,北京大学基础医学院柏林课题组在Nature Communications杂志在线发表了题为Structure and activation mechanism of the hexameric plasma membrane H+-ATPase的研究论文(https://doi.org/10.1038/s41467-021-26782-y)。该研究解析了自抑制(3.2 )和激...
探讨三磷酸腺苷(ATP)合酶在糖尿病大鼠阴茎海绵体平滑肌细胞病变中的作用机制。方法体内实验:40只SD大鼠随机分为正常对照组与糖尿病组(按60mg/kg腹腔内注射链脲佐菌素后72h、1周、2周随机血糖水平>16.7mmol/L为造模成功),饲养10周后比较大鼠阴茎勃起功能;处死后取阴茎海绵体组织,采用胶原纤维染色法检测纤维化程度,免疫组化法检测Caspase-3表达,Westernblot法检测F...
观察雷氏养心活血汤加味(Lei′s YXT)对心力衰竭大鼠的血压、Na+-K+-ATP酶、心钠素、血管紧张素Ⅱ水平等的影响。方法将SD雄性大鼠随机分成为空白对照组、阿霉素模型组、雷氏养心活血汤加味小剂量组、雷氏养心活血汤加味大剂量组、芪苈强心胶囊组、卡托普利组,每组10只,观察雷氏养心活血汤加味对大鼠收缩压、舒张压、平均压、心率、脉压、心肌张力时间指数、脏器指数、血糖、血脂、心肌酶、血清Na+-K...
探讨肿瘤患者术后舒芬太尼镇痛效应与μ阿片受体(mu-opioid receptor, OPRM1)、ATP结合盒B1基因(ATP-banding cassette, subfamily B, member 1 gene, ABCB1)、CYP3A基因多态性之间的联系。 方法 选择120例择期全身麻醉下行肿瘤切除术的患者,年龄19岁~65岁,ASA分级Ⅰ级、Ⅱ级,手术结束常规给予舒芬太尼静脉自控镇痛...
科学家发现有效抑制ATP-柠檬酸裂解酶的变构机制
科学家 ATP-柠檬酸裂解酶 变构机制 肿瘤治疗
2019/5/24
近日,美国哥伦比亚大学的科研人员在Nature上发表了题为“An allosteric mechanism for potent inhibition of human ATP-citrate lyase”的文章,研究人员对ATP-柠檬酸裂解酶(ACLY)的三维结构进行了解析,阐明了在抑制剂作用下的变构机制,为通过该分子靶标治疗肿瘤奠定了基础。ATP-柠檬酸裂解酶是一种ATP依赖性的中心代谢酶,负...
张志刚和孙勇伟课题组揭示细胞外ATP调控胰腺癌糖代谢新功能(图)
胰腺癌 上海市肿瘤研究所 国家自然科学基金
2023/1/16
2018年11月12日,国际著名临床肿瘤学杂志Clinical Cancer Research在线发表了来自上海交通大学附属仁济医院上海市肿瘤研究所张志刚研究员与上海交通大学附属仁济医院胆胰外科孙勇伟主任合作的题为“Targeting Purinergic Receptor P2Y2 prevents the growth of pancreatic ductal adenocarcinoma...
国家纳米科学中心聂广军课题组联合北京大学高宁课题组,利用天然蛋白质复合物,研发出一种具有肿瘤靶向作用及肿瘤微环境响应性的天然蛋白质纳米机器,实现在ATP的驱动下可控释放输水性抗肿瘤药物。相关研究成果“Chaperonin-GroEL as a Smart Hydrophobic Drug Delivery and Tumor Targeting Molecular Machine for Tumo...
ATP是细胞的能量货币,也是许多生命过程的重要信号物质。生理条件下,细胞的ATP浓度通常维持在十分稳定的水平,尤其是对于高耗能的心脏,剧烈运动时,其ATP的产生与消耗发生5-10倍的变化,而其ATP浓度却保持不变。那么心脏是如何维持ATP稳态平衡的?这看似简单的科学难题困扰着研究者们几十年。近日,北京大学分子医学研究所王显花课题组与中国第四军医大学高峰课题组合作,发现“线粒体炫(mitochond...
肿瘤微环境中一种新型促侵袭因子的发现——细胞外ATP功能及机制的研究进展
三磷酸腺苷 肿瘤微环境 肿瘤浸润 肿瘤转移
2018/12/4
根据世界卫生组织的最新统计数据,全球癌症每年新发病例约1 400多万人,同时约有820万人因癌症死亡,其中90%是因肿瘤的复发转移导致。恶性肿瘤给患者造成的危害关键就在于它能够转移,因此肿瘤转移始终是肿瘤防治的重大课题及研究难点。如果能够精准了解并掌握肿瘤转移的规律和机制,控制转移发生、发展的关键环节,肿瘤问题就能够得到根本的解决。
我们团队在过去近20年的研究工作中发现肿瘤微环境中存在的三磷酸...
Oral adenosine-5’-triphosphate (ATP) administration increases blood flow following exercise in animals and humans
Oral adenosine-5’-triphosphate (ATP) administration increases blood flow following exercise animals and humans
2015/7/29
Extracellular adenosine triphosphate (ATP) stimulates vasodilation by binding to endothelial ATP-selective P2Y2 receptors; a phenomenon, which is posited to be accelerated during exercise. Herein, we ...
Adenosine-5'-triphosphate (ATP) supplementation improves low peak muscle torque and torque fatigue during repeated high intensity exercise sets
ATP Adenosine-5’-triphosphate Muscle strength Muscle fatigue
2015/7/24
Intracellular concentrations of adenosine-5’-triphosphate (ATP) are many times greater than extracellular concentrations (1–10 mM versus 10–100 nM, respectively) and cellular release of ATP is ti...
Adenosine 5′-triphosphate (ATP) supplements are not orally bioavailable:a randomized, placebo-controlled cross-over trial in healthy humans
ATP Metabolism Nutritional supplement Bioavailability Gastrointestinal transit Multi-particulate supplement
2015/7/23
Nutritional supplements designed to increase adenosine 5′-triphosphate (ATP) concentrations are commonly used by athletes as ergogenic aids. ATP is the primary source of energy for the cells, and supp...
Mechanisms of Cytoskeletal Dysregulation in the Kidney Proximal Tubule During ATP Depletion and Ischemia
Dynamin AMPK Rho GTPases
2015/5/25
Knowledge of the molecular and cellular mechanisms of ischemic injury is necessary for understanding acute kidney injury and devising optimal treatment regimens. The cortical actin cytoskeleton in the...
Regulation of SRF Activity by the ATP-dependent Chromatin Remodeling Enzyme, CHD8
chromatin remodeling SRF apoptosis
2015/5/22
Under normal conditions, smooth muscle cells do not replicate, or proliferate, and provide a means of contraction for many internal organs, including blood vessels and the gut. However, under abnormal...
Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP
APE1 Ref-1
2014/12/12
Apurinic apyrimidinic endonuclease redox effector factor-1 (APE1/Ref-1) is involved both in the base excision repair (BER) of DNA lesions and in the eukaryotic transcriptional regulation. APE1/Ref-1 i...