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Penn-Engineered Neural Networks Show Hope for Axonal Repair in the Brain,with Minimal Disruption to Brain Tissue
Penn-Engineered Neural Networks Show Axonal Repair in the Brain Minimal Disruption to Brain Tissue
2016/2/22
Lab-grown neural networks have the ability to replace lost axonal tracks in the brains of patients with severe head injuries, strokes or neurodegenerative diseases and can be safely delivered with min...
Cyclooxygenase Inhibition Limits Blood-Brain Barrier Disruption following Intracerebral Injection of Tumor Necrosis Factor-alpha in the Rat
cyclooxygenase-2 COX-2 COX-1 prostaglandin E2 neuroinflammation blood-brain barrier ischemia stroke matrix metalloproteinase MMP-3 MMP-9 gelatinase B stromelysin-1 oxidative stress indomethacin cyclooxygenase-1 glutathione free radicals MRI
2015/7/29
Increased permeability of the blood-brain barrier (BBB) is important in neurological disorders. Neuroinflammation is associated with increased BBB breakdown and brain injury. Tumor necrosis factor-alp...
Barrier disruption in STAT6VT transgenic mice as a potential model for atopic dermatitis skin inflammation
STAT6VT transgenic Atopic Dermatitis
2015/5/25
Atopic dermatitis (AD) is a pruritic, chronic inflammatory skin disease with a lifetime prevalence of 10-20% in children and 1-3% in adults, worldwide. In the past three decades, prevalence of the dis...
G2 checkpoint abrogation as a cancer specific,cell cycle disruption
Cell Cycle G2 checkpoint DNA damage Chemo-sensitization Oncogenesis
2009/7/15
The majority of cancer cells are thought to have accumulated the necessary mutations for oncogenesis as a result of disrupting the cell cycle G1 checkpoint, leading to the replication of damaged DNA. ...
Psychologic Aspects of Disruption of Thumbsucking by Means of a Dental Appliance
Psychologic Aspects Disruption Dental Appliance
2009/3/16
Psychologic Aspects of Disruption of Thumbsucking by Means of a Dental Appliance.
Targeted disruption of the cation-dependent or cation-independent mannose 6-phosphate receptor does not decrease the content of acid glycosidases in the acrosome
cation-dependent cation-independent mannose 6-phosphate acid glycosidases acrosome
2008/12/25
The acrosome is a unique organelle containing acid hydrolases common to lysosomes as well as unique enzymes. Its ultimate exocytosis, as well as the absence of several lysosomal markers, has led to ...
Targeted disruption of the mouse prosaposin gene affects the development of the prostate gland and other male reproductive organs
mouse prosaposin gene prostate gland male reproductive organs
2008/12/25
The prosaposin gene encodes a 65-70 kilodalton (kd) protein, which is secreted or targeted to lysosomes. In lysosomes, prosaposin is the precursor of 4 activator proteins, designated saposins A, B...
Cytoskeleton Vimentin Disruption of Mouse Sertoli Cells Injured by Nitrogen Mustard In Vitro
Cytoskeleton Vimentin Disruption Mouse Sertoli Cells Injured by Nitrogen Mustard Vitro
2008/12/24
Reproductive toxicity is one of the potential side effects of anticancer alkylating agents, with potential effects on vimentin intermediate filaments, one of the main components of the Sertoli cytos...
EVALUATION OF THE PLEURAL DISRUPTION FOLLOWING COSTOCHONDRAL GRAFT HARVESTING FROM FOURTH TO SEVENTH RIBS OF ADULT MALE CADAVER
Costochondral graft rib graft pleural disruption cadaveric study
2010/4/6
Costochondral and rib grafts have long been used for reconstruction of lost condyle. Donor site morbidity has less been under investigation and researched. Pleural disruption pneumothorax and ugly sca...