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Engineered FADD Induces Apoptosis via an Artificial Death-Inducing Signaling Complex (DISC)
apoptosis FADD biotechnology DISC engineered protein
2009/10/26
An engineered Fas-associated death domain protein (FADD), 2DEDplusE—made previously by fusing the tandem DEDs of FADD to the E protein of lambda phage-greatly enhances apoptosis-inducing activity in a...
目的: 探讨FADD和Caspase-8表达缺失在肝细胞癌TRAIL耐受机制中的作用. 方法: 免疫组织化学方法检测肝细胞癌(hepatocellular carcinoma, HCC)组织中FADD蛋白的表达, 原位杂交方法检测HCC中Caspase-8的表达, 并结合临床资料进行分析. 采用TRAIL联合应用亚毒性剂量的化疗药及细胞因子, 观察其对于肝癌细胞株(HepG2、SMMC-7721)...
期刊信息
篇名
FADD-dependent apoptosis induction in Jurkat leukemia T-cells by the resveratrol analogue, 3,4,5-trihydroxy- trans-stilbene
语种
英文
撰写或编译
作者
Wang,Y.; Wang,B. Cheng,J.; Yang,L.; Liu,Z.-L.; Panta...