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The PI3K/AKT Pathway and FOXO3a Transcription Factor Mediate High Glucose-Induced Apoptosis in Neonatal Rat Ventricular Myocytes
Myocytes Cardiac Apoptosis gleditsioside B
2015/10/12
Background:: PI3K/AKT pathway plays major roles in regulating cardiomyocyte metabolism. The roles of PI3K/AKT pathway and FOXO3a in mediating high glucose-induced apoptosis in cardiomyocytes remain un...
Protective effects of antioxidants on high Glucose-induced malfunctions in human glomerular mesangial cells
Mesangial cells High glucose extracellular matrix
2009/12/31
Altered functions of mesangial cells induced by high glucose concentrations are thought to play an important role in the pathogenesis of diabetic nephropathy. We therefore investigated the effect of h...
DYS-REGULATION OF EXTRACELLULAR MATRIX PROTEINS TURNOVER BY HIGH GLUCOSE CONCENTRATIONS IN CULTURED HUMAN GLOMERULAR MESANGIAL CELLS
Fibronectin Collagen
2010/4/27
Diabetic glomerulopathy is generally believed to be the major cause for the development of chronic renal failure in diabetes mellitus. Diabetic glomerulosclerosis is characterized by the accumulation ...