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Variation of the Chloroquine Resistance Transporter (Crt) Gene in Chloroquine-Resistant and Chloroquine-Sensitive Plasmodium berghei
Chloroquine resistance Plasmodium berghei Crt gene
2009/12/11
Background: The emergence and spread of chloroquine resistant Plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rode...
Variation of the Chloroquine Resistance Transporter (Crt) Gene in Chloroquine-Resistant and Chloroquine-Sensitive Plasmodium berghei
Chloroquine resistance Plasmodium berghei Crt gene
2009/12/11
Background: The emergence and spread of chloroquine resistant Plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rode...
The in Vitro Effect of Plasmodium berghei Antigen Lysate on Natural Killer (NK) Cell Cytotoxic Activity
Natural killer (NK) cell cytotoxicity Plasmodium berghei
2009/7/2
Plasmodium berghei is the rodent equivalent of Plasmodium falciparum which causes cerebral malaria in humans. However, P. berghei does not cause cerebral malaria in BALB/c mice, instead it leads to pa...
IN VIVO EVALUATION OF COMBINATION EFFECTS OF CHLOROQUINE WITH CEPHARANTHIN® OR MINOCYCLINE HYDROCHLORIDE AGAINST BLOOD-INDUCED CHLOROQUINE-RESISTANT PLASMODIUM BERGHEI NK 65 INFECTIONS
Plasmodium berghei NK 65 Cepharanthin minocycline
2010/12/10
The combination effects of chloroquine with Cepharanthin® or minocycline hydrochloride were evaluated against a blood-induced infection with chloroquine-resistant P. berghei NK 65 in ICR mice. The...
用本所传代已二十余年、对药物敏感的伯氏鼠疟原虫作种源,每转种一代给小白鼠口服单次量咯萘啶。第1代剂量为8 mg/kg,其后剂量每代增加2 mg/kg。转种至第23代,剂量达2,400mg/kg时,虽部分小鼠死亡,存活小鼠的原虫血症仍不转阴,此时原虫的抗药性为亲代原虫的300倍以上。抗咯萘啶鼠疟原虫(RPB2)对氯喹、喹哌、吡咯喹、M-6407、阿的平与青蒿素等有一定程度的交叉抗药性。用对亲代原虫有...