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Alendronate reduces bone toughness of ribs without significantly increasing microdamage accumulation in dogs following three years of daily treatment
Bisphosphonates remodeling suppression
2014/12/4
Reduced bone toughness, the energy absorption capacity of the tissue, has been consistently documented in vertebrae of animals treated with a wide range of bisphosphonate doses. Data regarding toughne...
Theoretical analysis of alendronate and risedronate effects on canine vertebral remodeling and microdamage
bisphosphonate bone remodeling
2014/12/4
Bisphosphonates suppress bone remodeling activity, increase bone volume, and significantly reduce fracture risk in individuals with osteoporosis and other metabolic bone diseases. The objectives of th...
One Year of Alendronate Treatment Lowers Microstructural Stresses Associated with Trabecular Microdamage Initiation
bisphosphonate bone quality
2014/12/4
Alendronate, an anti-remodeling agent, is commonly used to treat patients suffering from osteoporosis by increasing bone mineral density. Though fracture risk is lowered, an increase in microdamage ac...
Can Deterministic Mechanical Size Effects Contribute to Fracture and Microdamage Accumulation in Trabecular Bone?
microdamage biomechanics fracture
2014/12/4
Failure of bone under monotonic and cyclic loading is related to the bone mineral density, the quality of the bone matrix, and the evolution of microcracks. The theory of linear elastic fracture mecha...