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PROTEIN PHOSPHATASE 2A (PP2A) HOLOENZYMES REGULATE DEATH ASSOCIATED PROTEIN KINASE (DAPK) IN CERAMIDE-INDUCED ANOIKIS
PROTEIN PHOSPHATASE 2A DAPK DEATH ASSOCIATED PROTEIN KINASE
2015/5/22
Modulation of sphingolipid-induced apoptosis is a potential mechanism to enhance the effectiveness of chemotherapeutic drugs. Ceramide is a pleiotropic, sphingolipid produced by cells in response to i...
Death-Associated Protein Kinase Regulates Vascular Smooth Muscle Cell Signaling and Migration
p65 MMP9 atherosclerosis
2015/5/22
Cardiovascular disease is the number one cause of death for Americans. New treatments are needed for serious conditions like atherosclerosis, as it can lead to stroke and heart attack. Many types of c...
Expression of 5′-AMP-activated Protein Kinase with Starvation in Murine Thymocytes
AMP-activated protein kinase Thymocyte Glucocorticoid
2011/6/10
The 5′-AMP-activated protein kinase (AMPK) is a key enzyme in the protection of cells during energy crisis. AMPK is a heterotrimer consisting of a catalytic α (α1, 2) subunit and two regulatory subuni...
IFN-g-Mediated Transcriptional Induction of the IDO (Indolamine 2,3-Dioxygenase) Gene Requires Activity of p68/PKR Protein Kinase
IFN p68/PKR IDO transcription
2009/6/26
We investigated whether the activity of double-stranded RNA activated kinase (p68/PKR) is necessary for induction of IDO (indolamine 2,3 -dioxygenase) gene by IFN-g. For this purpose, we planned to ab...
A comparative analysis of cAMP-dependent protein kinase regulatory subunits in sea urchin and rat spermatozoa
spermatozoa azido photoprobes protein kinase nucleotides epididymis
2009/2/23
8-Azido cAMP photoaffinity labeling of cAMP-dependent protein kinase regulatory subunits (R1 = 49 K;R2 = 55K) was done on spermatozoa from species lacking, and species containing an epididymis. Sper...
The aging Leydig cell. VIII. Protein kinase activity
The aging Leydig cell Protein kinase activity
2009/2/19
The effects of aging on cyclic AMP (cAMP) dependent protein kinase activity of purified Leydig cells were evaluated. Purified Leydig cells from 20-day-, 40-day-, 60-day- and 30-month-old rats were...
Protein kinase CK2 activities in human prostatic and seminal-vesicle secretions and seminal plasma
Prostate vasectomy normozoospermia oligozoospermia
2009/2/18
Human prostatic secretion and seminal plasma contain certain protein kinase activities. Protein kinases play important roles in regulating a vast variety of cellular functions. The objective of this...
Atrial natriuretic factor inhibits the phosphorylation of protein kinase C in plasma membrane preparations of cultured Leydig tumor cells
Atrial natriuretic factor protein kinase C Leydig tumor cells cGMP plasma membranes
2009/2/12
The peptide hormone atrial natriuretic factor (ANF) exerts its effect in a receptor-mediated fashion and the membrane-bound form of guanylate cyclase represents a biologically active ANF receptor;...
Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells
Calcium calmodulin glucocorticoid action oxidoreductases
2008/12/30
Glucocorticoid hormone controls Leydig cell steroidogenic function through a receptor-mediated mechanism. The enzyme 11beta-hydroxysteroid dehydrogenase (11betaHSD) plays an important role in Leydig...
Stage- and Cell-Specific Expression of Soluble Guanylyl Cyclase Alpha and Beta Subunits, cGMP-Dependent Protein Kinase I Alpha and Beta, and Cyclic Nucleotide-Gated Channel Subunit 1 in the Rat Testis
Cyclic guanosine monophosphate sGC PKG-I CNG-1
2008/12/23
Several studies suggest that nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) modulate testicular function. In this study, we examined the expression of cGMP-dependent protein kinase ...
Exogenous Protein Kinases A and C, But Not Endogenous Prostasome-Associated Protein Kinase, Phosphorylate Semenogelins I and II From Human Semen
Acid phosphatase histone prostate-specific antigen vasectomy
2008/12/15
Semenogelins I and II are the quantitatively dominating proteins in human semen. They comprise the major part of the sperm-entrapping gel formed at ejaculation, which subsequently liquefies due to pro...
Activation of Protein Kinase A During Human Sperm Capacitation and Acrosome Reaction
Phosphodiesterases cyclic adenosine monophosphate calcium ionophore A23187 signal transduction
2008/12/15
Spermatozoa undergo a variety of changes during their life that are prerequisites to their maturation and ability to fertilize eggs. Mammalian sperm capacitation and acrosome reaction are regulated by...
Protein kinase C increases 11beta-hydroxysteroid dehydrogenase oxidation and inhibits reduction in rat Leydig cells
Protein kinase C 11beta-hydroxysteroid dehydrogenase oxidation inhibits rat Leydig cells
2008/12/1
Glucocorticoid hormone controls Leydig cell steroidogenic function through a receptor-mediated mechanism. The enzyme 11beta-hydroxysteroid dehydrogenase (11betaHSD) plays an important role in Leyd...
Role of Protein Kinase C in Eosinophil Function
eosinophils PKC inhibitors PKC isoform protein kinase C (PKC) signal transduction
2010/11/19
Protein kinase C (PKC) isoforms are being elucidated as an increasingly diverse family of enzymes involved in the downstream signal transduction and cell function in various types of cells. To date, 1...
Production of Matrix Metalloproteinases in Human Cultured Mast Cells: Involvement of Protein Kinase C—Mitogen Activated Protein Kinase Kinase—Extracellular Signal-regulated Kinase Pathway
human cultured mast cells matrix metalloproteinase-9 membrane type matrix metalloproteinase tissue inhibitor of metalloproteinase-1 tissue inhibitor of metalloproteinase-2
2010/11/18
We detected the de novo synthesis of MMP-9 in HCMC after stimulation with PMA and found that the synthesis was mediated through protein kinase C—mitogen activated protein kinase kinase (MEK)—ERK pathw...