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华南理工大学医学院张文清课题组在Leukemia发文，发现斑马鱼Asxl1基因突变影响中性粒细胞发育（图）
华南理工大学医学院 张文清 Leukemia 斑马鱼 Asxl1基因突变影响 中性粒 细胞发育
2021/2/23
髓系恶性肿瘤（myeloid malignancies）是一类严重影响人类生命健康的血液疾病，它主要包括慢性阶段的骨髓增生异常综合征（myelodysplastic syndromes，MDS）、骨髓增生性肿瘤（myeloproliferative neoplasms，MPN）、慢性粒单核细胞白血病（chronic myelomonocytic leukemia，CMML）和急性阶段的急性髓系白血...
由上海交通大学基础医学院细胞凋亡与分化教育部重点实验室洪登礼和陈国强课题组、上海交通大学医学院附属上海儿童医学中心汤燕静教授和中国科学院动物研究所刘峰研究员共同合作完成的一项成果揭示了胚胎造血调控因子FEV的表达可以指示出生前起源的白血病，该成果于2016年12月9日以“Expression of the fetal hematopoiesis regulator FEV indicates le...
Xenotropic Murine Leukemia Virus-Related Virus and RNase L R462Q Variants in Iranian Patients With Sporadic Prostate Cancer
Xenotropic Murine Leukemia Virus-Related Virus Polymorphism RNase L Prostate Cancer
2015/12/29
Background: Although several studies have confirmed the association of xenotropic murine leukemia virus-related virus (XMRV) and prostate cancer, this association is still controversial, as most studi...
ERK1 AND ERK2 IN HEMATOPOIESIS, MAST CELL FUNCTION, AND THE MANAGEMENT OF NF1-ASSOCIATED LEUKEMIA AND TUMORS
hematopoiesis neurofibroma leukemia
2015/5/25
Neurofibromatosis type 1 is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene, which encodes a protein serving, at least in part, to acce...
ZAP70 Expression Within del6q21, del11q13 and del17p13 Cytogenetic Subgroups of Iranian Patients with Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia ZAP70 Expression Chromosomal Abnormality
2015/10/15
Background: B-cell chronic lymphocytic leukemia (B-CLL) is the most common form of leukemia in adults. Some reports showed that expression of ZAP70 gene and chromosomal abnormality are two prognostic ...
FISH Analysis for del6q21 and del17p13 in B-cell Chronic Lymphocytic Leukemia in Iranians
Leukemia Lymphocytic Chronic B-Cell Cytogenetic Aberrations Biological Markers
2015/9/29
Background: B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia in the Western world. Major progress has been made in assessing typical chromosomal abnormalities and recognition of...
Correlates of Age at Initial Diagnosis of Chronic Lymphocytic Leukemia: Exercise, ASA & Emotional Distress
Chronic Lymphocytic Leukemia Stress Aspirin
2013/8/30
Objective: No studies of either the cross-sectional or prospective association of behavioral lifestyle characteristics and the onset of Chronic Lymphocytic Leukemia (CLL) exist. Methods: Multiple inte...
Correlates of Age at Initial Diagnosis of Chronic Lymphocytic Leukemia: Exercise, ASA & Emotional Distress
Chronic Lymphocytic Leukemia Stress Aspirin
2013/1/31
Objective: No studies of either the cross-sectional or prospective association of behavioral lifestyle characteristics and the onset of Chronic Lymphocytic Leukemia (CLL) exist. Methods: Multiple inte...
Association between MDR1 C3435T Gene Polymorphism and Acute Lymphoblastic Leukemia (ALL) in Iranian Population
P-glycoprotein MDR1 Acute lymphoblastic leukemia C3435T polymorphism
2015/9/21
Background: P-glycoprotein (P-gp), an ATP-dependent efflux pump, is a membrane protein encoded by MDR1 gene. P-gp has an important role in protection of the cell against xenobiotics and toxic compound...
Correlation of del13q, del11q and Trisomy 12 with Laboratory and Clinical Features of Chronic Lymphocytic Leukemia in Iranian Patients
Chronic lymphocytic leukemia Chromosomal aberrations Rai stages CD markers Iran
2015/9/21
Background: There is a strong association between chromosomal abnormalities and laboratory features and clinical course of the B-cell chronic lymphocytic leukemia (B-CLL). The aim of this study was to...
Vitamin D Dependent Down Regulation of Arf1 Gene in Human Leukemia Cell Line HL-60
Gene expression ARF1 Vitamin D Real-Time RT-PCR
2009/6/24
ADP-ribosylation factor 1 (ARF1) is a gene belonging to the ARF gene family. ARF genes, small guanine nucleotide-binding proteins, constitute a family of the RAS superfamily. This superfamily function...
Comparative Cytotoxicity of Fludarabine in Human Peripheral Blood Mononuclear Cells and in the Promyelocytic Leukemia Cell Line (HL60)
HL60 MTT assay fludarabine cytotoxicity differentiation
2009/6/23
Fludarabine is an inhibitor of DNA/RNA synthesis with antitumor activity on lymphoproliferative malignancies. We investigated the dose-dependent cytotoxic effects of the drug on human peripheral blood...
Adhesion of Beta1 Integrin to Fibronectin Regulates CAM-DR Phenotype via p21WAF1/cip1 in HL60 Acute Myeloid Leukemia (AML) Cells
Apoptosis CAM-DR fibronectin cell cycle
2009/6/16
Aims: Drug resistance is a major obstacle for a successful cancer therapy. Cell adhesion mediated drug resistance (CAM-DR) is a novel type of drug resistance and generated via interaction of cancer ce...
Chlorambucil and fludarabine as a new pre-transplant conditioning for patients with chronic lymphocytic leukemia: results of in vivo experiments
rat haematological toxicity non-haematological toxicity
2015/3/17
Chronic lymphatic leukemia (CLL), incurable by standard treatments, may be potentially cured by
allogeneic hematopoietic stem cell transplantation. Since CLL affects predominantly older people, ther...
COMPARISON OF LIPOAMIDE DEHYDROGENASE ACTIVITY IN HL-60 LEUKEMIA CELLS AND NORMAL LYMPHOCYTE
Lipoamide dehydrogenase Lymphocyte HL-60
2010/4/19
To determine the importance of Q10H2 as an antioxidant in cancer, we measured the activity of lipoamide dehydrogenase (Q10H2 recycling enzyme) in HL-60 and normal lymphocyte. The cultured cells of HL-...