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NEUROPROTECTIVE EFFECT OF THYROTROPIN-RELEASING HORMONE (TRH) AGAINST GLUTAMATE TOXICITY IN VITRO
Heterologous Receptor Downregulation PC12 Cell Culture GH-3 Cell Culture G alpha q/11 Hippocampal Slice Superfusion TRH Neuroprotection
2015/5/21
Acute and chronic activation of both ionotropic and metabotropic glutamate (glut) receptors is implicated in many neurodegenerative disorders including AD, dementia, epilepsy, stroke and neurotrauma. ...
用雄性Wistar大鼠,采用Feeney等的落体撞击法造成左顶颅脑挫伤。动物随机分组,给于TRH类似物YM14673(0.1 mg·kg-1或1.0 mg.kg-1,ip)或等体积生理盐水。治疗组可明显地减轻脑水肿。