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DIFFERENTIAL ROLE OF PI-3KINASE p85 (α & β) REGULATORY SUBUNITS IN MAST CELL DEVELOPMENT
Cell cycle -- Regulation Enzymes
2015/5/25
Stem cell factor (SCF) mediated c-Kit signaling, and downstream activation of Phosphatidylinositol-3 Kinase (PI-3K) is critical for multiple biological effects mediated by mast cells. Mast cells expre...
ERK1 AND ERK2 IN HEMATOPOIESIS, MAST CELL FUNCTION, AND THE MANAGEMENT OF NF1-ASSOCIATED LEUKEMIA AND TUMORS
hematopoiesis neurofibroma leukemia
2015/5/25
Neurofibromatosis type 1 is a genetic disease that results from either heritable or spontaneous autosomal dominant mutations in the NF1 gene, which encodes a protein serving, at least in part, to acce...
Differences in mast cell-bound IgE in the nasal epithelial layer and lamina propria
allergic rhinitis IgE immunohistochemistry mast cell nasal mucosa
2010/11/25
Mast cells in the allergic nasal mucosa are reported to have higher concentrations of high affinity type I Fcε receptors (FcεRI) than mast cells in the non-allergic mucosa. IgE binds to FcεRI on mast ...
Human mast cell activation through Fc receptors and Toll-like receptors
adaptive immunity FcεRI FcγRI GeneChip innate immunity mast cell Toll-like receptor 4
2010/11/22
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE. Recent studie...
Suplatast Tosilate Inhibits Human Mast Cell Development from Cord Blood Progenitors
cord blood progenitors human mast cells stem cell factor suplatast tosilate
2010/11/19
Background: Localized mast cell accumulation has been reported in a number of human diseases. Suplatast tosilate has been reported to inhibit IL-3-dependent murine mast cell development, and therefore...