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急性髓系白血病(Acute Myeloid Leukemia,AML)是造血系统的髓系原始祖细胞恶性增殖性疾病。据美国癌症协会估计,2022年美国急性髓系白血病的发病病例约20050例,死亡病例约11540例。尽管AML的发病机制研究和临床前研究取得了显著进展,但AML患者的5年生存率仍然很差(< 40%)。因此,临床上急需开展基于新靶点、新机制的抗AML药物研究。
探讨抑制性寡脱氧核苷酸(suppressive oligodeoxynucleotide,Sup ODN)对刀豆蛋白A(ConA)诱导肝损伤小鼠兔抗鼠磷酸化信号转导和转录激动子4抗体 (pSTAT4) 、pSTAT6和Tbet表达的影响及其意义。方法Balb/C小鼠40只被随机分为4组,分别为生理盐水(NS,空白对照)组、环孢菌素A(CsA)组(阳性对照)、Con ODN组(对照ODN)、Sup...
目的: 探讨哮喘患者PBMCs中转录因子T-bet/GATA-3比率与Th1/Th2细胞失衡的关系及体外CpG干预后T-bet/GATA3比率的变化及其对Th1/Th2细胞平衡的调节作用。方法: 用RT-PCR法测定30例发作期哮喘患者(哮喘组)及20例慢性阻塞性肺病患者(COPD组)及20例正常人(对照组) PBMCs中T-bet mRNA、GATA-3 mRNA及TLR9 mRNA的表达强度,...
Detection of Specific IgE Antibodies in Sera of Japanese Birch-Allergic Patients Using Recombinant Allergens Bet v 1, Bet v 2 and Bet v 4
Bet v 1 Bet v 2 birch pollinosis RAST
2010/11/17
Background: Birch pollen is the major allergen in pollinosis in northern Japan. IgE reactivity to individual birch pollen allergens has been shown to differ between populations of birch pollen-allergi...
Measurement of IgE and IgG4 antibodies against purified grass pollen allergens (Phl p 1, Phl p 2, Phl p 5 and Bet v 2) and natural extracts after short-term grass immunotherapy
grass pollen allergy IgE IgG4 immunotherapy olive pollen recombinant allergens
2010/11/25
We wanted to define allergen-specific antibodies that change due to specific immunotherapy. We conducted a study with grass pollen-allergic patients and compared allergen-specific IgE and IgG4 before ...