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2019年11月13日,浙江大学医学院附属口腔医院王慧明教授团队在STEM CELLs(干细胞领域权威期刊之一)上在线发表题为“KLF2+ stemness maintains human mesenchymal stem cells in bone regeneration”的研究论文,首次提出采用KLF2作为人骨髓间充质干细胞(hMSCs)体外标志物,并研究KLF2+hMSCs在血管再生和骨组...
Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad
autocrine signaling bone marrow cells breast cancer
2014/11/6
Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB...
Effect of Stretching Stress on Gene Transcription Related to Early-phase Differentiation in Rat Periodontal Ligament Cells
Periodontal ligament Mechanical stress Homeostasis
2010/12/1
Mechanical stress such as occlusal and orthodontic loading has been suggested to induce a homeostatic and regenerative response in periodontal ligament (PDL), but the underlying mechanism remains to b...
The cytomorphological analysis of buccal mucosa cells in smokers
Oral exfoliative cytology cytomorphometry smoking buccal mucosa
2011/3/22
To examine the effect of smoking on normal buccal mucosa cytomorphologically. Materials and methods: Forty individuals aged between 40 and 60, comprising 23 smokers (14 male, 9 female) and 17 and non-...
Effect of chondroitin sulfate-E on the osteoclastic differentiation of RAW264 cells
Chondroitin sulfate Osteoclast Calcium phosphate
2010/11/29
The present study was designed to investigate whether chondroitin sulfate (CS)-E, a CS structural isomer variant, alter the differentiation of macrophage cell line RAW264 cells to osteoclast-like cell...
Proliferation and differentiation potential of pluripotent mesenchymal precursor C2C12 cells on resin-based restorative materials
Restorative materials Resins Mesenchymal cells
2010/11/29
This study investigated the proliferation and differentiation potential of pluripotent mesenchymal cells on three resin-based restoratives using a typical pluripotent mesenchymal precursor cell line, ...
Fluoride does not induce DNA breakage in Chinese hamster ovary cells in vitro
Sodium fluoride Comet assay Mutagenicity tests
2009/10/20
Fluoride has been widely used in dentistry because it is a specific and effective caries prophylactic agent. However, excess fluoride may represent a hazard to human health, especially by causing inju...
Response of osteoblastic cells to titanium submitted to three different surface treatments
Titanium Surface properties Osteoblasts Biocompatible materials
2009/10/20
In the complex process of bone formation at the implant-tissue interface, surface properties are relevant factors modulating osteoblastic function. In this study, commercially pure titanium (cp Ti) sa...
Adherence to HeLa cells, typing by killer toxins and susceptibility to antifungal agents of Candida dubliniensis strains
Candida Cell adhesion Acquired immunodeficiency syndrome HIV
2009/10/16
The aim of this study was to evaluate the adherence capability to HeLa cells, the susceptibility to killer toxins and the in vitro susceptibility to antifungal agents (eTest? method - AB Biodisk, Soln...
Interstitial and Langerhans' dendritic cells in chronic periodontitis and gingivitis
Periodontitis Gingivitis Dendritic cells CD1a Factor XIIIa
2009/10/16
The aim of the present study was to compare quantitatively the distribution of dendritic cell subpopulations in chronic periodontitis and gingivitis. Fourteen biopsies from patients with chronic perio...
Accumulation of Element Ti in Macrophage-like RAW264 Cells Cultured in Medium with 1 ppm Ti and Effects on Cell Viability, SOD Production and TNF-α Secretion
Macrophage Titanium Phagocytosis
2009/9/15
The adverse effect of Ti on body-defense macrophage is not well understood. The aims of this study were twofold: (1) to examine the intracellular accumulation of Ti element; and (2) to measure the cel...
Global Gene Expression Analyses of Mouse Fibroblast L929 Cells Exposed to IC50 MMA by DNA Microarray and Confirmation of Four Detoxification Genes' Expression by Real-time PCR
MMA cDNA microarray Gene expression
2009/9/14
Methyl methacrylate (MMA) is the main component of methyl methacrylic resin, which is widely used in dentistry. Previous studies have investigated whether MMA has any adverse effects on growth and gen...
Gene Expression of MC3T3-E1 Cells on Fibronectin-immobilized Titanium Using Tresyl Chloride Activation Technique
Osteoblasts Fibronectin-titanium GeneChip
2009/9/14
Fibronectin (FN) can be immobilized directly on titanium surfaces using tresyl chloride activation technique. The key advantage of tresyl chloride activation technique lies in its simplicity. In this ...
Development of Cell-hybrid Artificial Bone: Effect of Osteogenic Differentiation of Bone Marrow Stromal Stem Cells on Bone Formation with Newly Developed Interconnected Porous Calcium Hydroxyapatite
Interconnected porous calcium hydroxyapatite Bone regeneration Cell-hybrid artificial bone
2009/9/14
The purpose of this study was to evaluate the effect of osteogenic differentiation of bone marrow stromal stem cells (BMSCs) on bone formation in a novel interconnected porous calcium hydroxyapatite (...
Effect of surface roughness on initial responses of osteoblast-like cells on two types of zirconia
Zirconia Surface roughness Osteoblast
2009/9/11
The aim of this study was to evaluate the effect of surface roughness on the initial attachment of mouse osteoblast-like cells on ceriastabilized zirconia/alumina nanocomposite (NANOZR) and yttria-sta...