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Origin and fate of autophagosomes in Leydig cells of normal adult rats
Origin fate autophagosomes Leydig cells normal adult rats
2009/2/23
Autophagosomes were observed frequently in electron microscope photographs of Leydig cells from normal adult rat testis. Their formation, evolution and fate were analyzed morphologically in preparat...
Modification of Sertoli Cell Responsiveness to FSH by Cryptorchidism and Hypophysectomy in Immature and Adult Rats
rat cryptorchidy hypophysectomy cAMP Sertoli cell
2009/2/19
Cryptorchid or hypophysectomized rats were used as models to examine the possible relationships between germ cell development and gonadotropins in the agerelated decline in the responsiveness of t...
Abnormalities of the Hypothalamic—Pituitary—Leydig Cell Axis in Young Adult Rats with Vitamin A Deficiency
vitamin A deficiency (VAD) hypogonadism testosterone Leydig cell hypothalamus
2009/2/19
The hypothalamic concentration of gonadotrophin releasing hormone (GnRH), the in vivo pituitary responses to GnRH, and the in vivo Leydig cell responses to bovine luteinizing hormone (LH) and to end...
FSH immunoneutralization acutely impairs spermatogonial development in normal adult rats
FSH immunoneutralization spermatogonial development adult rats
2009/2/18
Follicle-stimulating hormone (FSH) plays an important part in testicular development. Its role in the regulation of spermatogenesis in the adult, however, remains controversial. This study aimed t...
Immunocytochemical localization of the Ya, Yb1, Yc, Yf, and Yo subunits of glutathione S-transferases in the cauda epididymidis and vas deferens of adult rats
Immunocytochemical localization Ya Yb1 Yc Yf glutathione S-transferases cauda epididymidis
2009/2/18
Glutathione S-transferases (GSTs) are dimeric proteins grouped into five classes based on the degree of amino acid homology of their subunits. They are involved in cellular detoxification through ...
Testosterone-dependent restoration of spermatogenesis in adult rats is impaired by a 5alpha-reductase inhibitor
Testosterone-dependent restoration spermatogenesis adult rats 5alpha-reductase inhibitor
2009/2/18
Germ cell development (spermiogenesis in particular) in the adult rat is known to be testosterone dependent. Recently we proposed a role for the 5alpha reduction of testosterone to dihydrotestostero...
Follicle-stimulating hormone is required for the initial phase of spermatogenic restoration in adult rats following gonadotropin suppression
Testosterone germ cell spermatogonia stereology
2009/2/18
The role of follicle-stimulating hormone (FSH) in adult rat spermatogenesis is unclear. Although exogenous testosterone (T) restores spermatogenesis following gonadotropin-releasing hormone (GnRH)...
Testosterone and spermatogenesis: evidence that androgens regulate cellular secretory mechanisms in stage VI-VIII seminiferous tubules from adult rats
Testosterone spermatogenesis androgens regulate cellular secretory mechanisms adult rats
2009/2/13
The aim of this study was to investigate the effect of testosterone manipulation on the quantitative synthesis and secretion of a number of specific proteins produced by seminiferous tubules (ST) ...
Can spermatogenesis be maintained quantitatively in intact adult rats with exogenously administered dihydrotestosterone?
spermatogenesis adult rats with dihydrotestosterone
2009/2/12
It is well established that testosterone (T) is required to maintain spermatogenesis in the mammalian testis, presumably acting through a receptor mechanism, as elsewhere. It is puzzling, however,...
Inhibition of steroidogenesis in neonatal Leydig cells by unknown factor（s）present in spent media of androgen-treated cultured testicular cells from adult rats
Leydig cell 5a-dihydrotestosterone methyltrienolone
2009/2/12
Treatment of cultured testicular cells from adult rats with 5 alpha-dihydrotestosterone (DHT; 10(-6) M) or the synthetic androgen methyltrienolone (R1881; 10(-6) M) inhibited Leydig cell 3 beta-hy...
Effects of follicular fluid administration on serum bioactive and immunoreactive FSH concentrations and compensatory testosterone secretion in hemicastrated adult rats
Rat hemicastration follicle-stimulating hormone(FSH) testosterone inhibin
2009/2/7
In adult rats, removal of one testis (hemicastration) results in an elevation of serum follicle-stimulating hormone (FSH) concentrations and a compensation in testosterone secretion by the remain...
Effects of hypophysectomy and alterations in spermatogenic function on Leydig cell volume, number, and proliferation in adult rats
Pituitary spermatogenesis luteinizing hormone Leydig cell proliferation
2009/2/6
The two major objectives of this study were to determine (i) whether the pituitary is required to maintain Leydig cell number per testis, and (ii) whether alterations in spermatogenic function in ...
Expression and Regulation of Aquaporins 1, 8, and 9 in the Testis, Efferent Ducts, and Epididymis of Adult Rats and During Postnatal Development
channels Sertoli cells Leydig cells principal cells clear cells nonciliated cells
2008/12/30
Aquaporins (AQPs) are membrane protein channels that allow the rapid passage of water through an epithelium containing tight junctions. In the present study, light microscope immunocytochemistry ...
Prenatal exposure to dexamethasone alters Leydig cell steroidogenic capacity in immature and adult rats
Testis neuroendocrine luteinizing hormone testosterone
2008/12/29
This study examines the effects of prenatal exposure to dexamethasone (DEX) on postnatal testosterone production in male rats. Pregnant female rats were treated on gestation days 14-19 with DEX (1...
Mullerian inhibiting substance inhibits testosterone synthesis in adult rats
Anti-Mu llerian hormone primary Leydig cells
2008/12/29
Mullerian inhibiting substance (MIS) is a gonadal hormone that causes regression of the Mullerian ducts during male sexual differentiation. Postnatally, MIS inhibits the proliferation and differen...