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Structural Basis for the Inhibition of SARS-CoV-2 Main Protease by Antineoplastic Drug Carmofur
SARS-CoV-2 cross-neutralizing antibody receptor binding motif spike protein substitution mutation
2020/6/11
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of...
Inhibition of SARS-CoV-2 (Previously 2019-nCoV) Infection by a Highly Potent Pan-Coronavirus Fusion Inhibitor Targeting Its Spike Protein That Harbors a High Capacity to Mediate Membrane Fusion
Inhibition SARS-CoV-2 Pan-Coronavirus Fusion Inhibitor Targeting High Capacity Mediate Membrane Fusion
2020/6/12
The recent outbreak of coronavirus disease (COVID-19) caused by SARS-CoV-2 infection in Wuhan, China has posed a serious threat to global public health. To develop specific anti-coronavirus therapeuti...
期刊信息
篇名
Molecular Recognition of Macrocyclic Polymines to RNA and Their Inhibition of HIV-1 TAT-RNA Interaction
语种
英文
撰写或编译
撰写
作者
Meirong Hao,Ming Yang
第一作者单位
刊物名称
U.S.Chinese Journal of Microbi
页面
20...
Sex differences in the inhibition of γ-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects
dietary sesame oil healthy subjects
2016/12/30
Our aim was to determine the extent to which dietary sesame lignans alter human α- and γ-tocopherol metabolism and elimination as carboxyethyl hydroxychromanols (CEHCs).
Inhibition of lipolysis improves insulin sensitivity in protease inhibitor–treated HIV-infected men with fat redistribution
Lipodystrophy insulin resistance fatty acids
2016/12/29
Acute inhibition of lipolysis and reduction in fatty acid concentrations are associated with improved insulin sensitivity in patients with HIV lipodystrophy and hyperinsulinemia. Further studies are n...
Inhibition of cholesterol absorption by phytosterol-replete wheat germ compared with phytosterol-depleted wheat germ
Diet human studies phytosterols
2017/1/3
The objective was to establish whether the selective removal of phytosterols from wheat germ would increase the cholesterol absorption measured from test meals composed of wheat germ muffins.