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The steps in the development of important medical discoveries rest first on intuition and then on associations of a certain factor with a disease, followed by scientifically designed experiments. T...
Background: Increased fish or fish-oil consumption is associated with reduced risk of cardiac mortality, especially sudden death. This benefit putatively arises from the incorporation of the long-chai...
Background: Regular exercise and consuming long-chain n–3 fatty acids (FAs) from fish or fish oil can independently improve cardiovascular and metabolic health, but combining these lifestyle modificat...
In evaluating the cardiovascular merits of n–3 fatty acids, Wang et al (1) appropriately sought the best available evidence and used randomized controlled human trials (RCTs) as their benchmark. As th...
Eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and γ-linolenic acid (GLA) have lipid-modifying and antiinflammatory properties. The effects of supplement mixtures of these fatty acids on pla...
Prostaglandin E2 (PGE2) inhibits lymphocyte proliferation and the production of interferon-γ (IFN-γ) by peripheral blood mononuclear cells, but the effect of PGE2 on interleukin 4 (IL-4) production is...
Background: Tumor necrosis factor α (TNF-α) mediates inflammation. High TNF-α production has adverse effects during disease. Polymorphisms in the TNF-α and lymphotoxin α genes influence TNF-α producti...
n23 Fatty acids have been shown to modify several key risk factors for cardiovascular disease. However, it is not clear whether the apparent protection against cardiovascular disease is directly re...

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