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Consideration of betaine and one-carbon sources of N5-methyltetrahydrofolate for use in homocystinuria and neural tube defects1,2
Betaine methyltetrahydrofolate homocystinuria neural tube defects
2008/12/12
A major focus in attempts to ameliorate homocystinuria and neural tube defects is supplementation of the diet with B vitamins. The metabolic defect in these cases may be due in part to a deficiency of...
Maternal smoking is associated with decreased 5-methyltetrahydrofolate in cord plasma1,2,3
5-Methyltetrahydrofolic acid folate folic acid African American women pregnancy smoking electrospray mass spectrometry
2008/12/12
Background:Maternal-fetal folate transport via the placenta has been shown to be concentrative. Exposure to cigarette smoke is associated with decreased maternal folate status through altered dietary ...
Comparison of the effect of low-dose supplementation with L-5-methyltetrahydrofolate or folic acid on plasma homocysteine: a randomized placebo-controlled study
homocysteine plasma folate red blood cell folate,
2016/12/29
Food fortification with folic acid has been introduced in several countries for the prevention of neural tube defects. Fortification has lowered total homocysteine (tHcy) concentrations in the US popu...
5,10-Methylenetetrahydrofolate reductase genotype determines the plasma homocysteine-lowering effect of supplementation with 5-methyltetrahydrofolate or folic acid in healthy young women
MTHFR genotype homocysteine folic acid methyltetrahydrofolate methylenetetrahydrofolate reductase supplementation women
2016/12/17
Background: Elevated plasma total homocysteine (tHcy) is a risk factor for vascular disease and neural tube defects. The polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase...