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Objective. To provide students with an opportunity to participate in medicinal chemistry research within the doctor of pharmacy (PharmD) curriculum. Design. We designed and implemented a 3-course seq...
DecursivineSerotobenine是一类具有苯并二氢呋喃,吲哚并八元内酰胺多环体系的吲哚生物碱,分别具有抗疟疾及广泛的抗菌活性,其良好的生物活性和独特新颖的结构,引起了合成化学家的关注。其中Michael A. Kerr小组以18步3%的总收率首次完成了(±)-Decursivine的全合成,Tohru Fukuyama小组以24步8%的总收率首次完成了(-)-Serotobenin...
Metronidazole (MTZ) and its derivatives have been extensively used to treat infections caused by protozoa and anaerobic bacteria. In this investigation several novel imidazole and nitroimidazol deriva...
A group of racemic 3-[(2-hydroxyethyl), (2-Methoxyethyl), (2-acetylethyl) or (2-cyanoethyl)], 5- methyl, ethyl or isopropyl-1, 4-dihydro-2, 6-dimethyl-4-(1-methyl-5-nitro-2-imidazolyl)-3, 5-pyridinedi...
Background and purpose of the study: The vasorelaxant action of the dihydropyridines (DHPs) provides many useful clinical indications. However, their negative effects on cardiac contractility is still...
Several novel 2-amino-5-[4-chloro-2-(2-chlorophenoxy)phenyl]-1,3,4-thiadiazole derivatives 4a-d were synthesized and their anticonvulsant activity was determined by evaluation of the ability of theses...
5-Fluorouracil and methotrexate are antimetabolites widely used in the treatment of neoplastic disease. They act by inactivating the two enzymes involved in the biosynthesis of the pyrimidine nucleoti...

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