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Signaling mechanisms that suppress the anabolic response of osteoblasts and osteocytes to fluid shear stress
Mechanotransduction Osteoblast Osteocyte
2015/5/22
Bone is a dynamic organ that responds to its external environment. Cell signaling cascades are initiated within bone cells when changes in mechanical loading occur. To describe these molecular signali...
Nmp4/CIZ suppresses the response of bone to anabolic parathyroid hormone by regulating both osteoblasts and osteoclasts
c-fos Fra-2 osteoclastogenesis
2014/11/6
How parathyroid hormone (PTH) increases bone mass is unclear, but understanding this phenomenon is significant to the improvement of osteoporosis therapy. Nmp4/CIZ is a nucleocytoplasmic shuttling tra...
Megakaryocytes Regulate Expression of Pyk2 Isoforms and Caspase-mediated Cleavage of Actin in Osteoblasts
actin bone osteoblasts
2014/11/6
The proliferation and differentiation of osteoblast (OB) precursors are essential for elaborating the bone-forming activity of mature OBs. However, the mechanisms regulating OB proliferation and funct...
Effect of Excessive Vitamin A on Alkaline Phosphatase Activity and Concentrations of Calcium-binding Protein and Bone Gla-protein in Culture Medium and CaBP mRNA Expression in Osteoblasts of Broiler Chickens
Vitamin A Broiler Chicken Calcium-binding Protein mRNA Expression Osteoblast Bone Gla-protein
2016/5/6
This study was conducted to determine the effects of excess vitamin A on alkaline phosphatase (ALP) activity, contents of calcium-binding protein (CaBP), bone gla-protein (BGP) in culture medium and C...
1α,25-dihydroxyvitamin D3 Rapidly Modulates Ca2+ Influx in Osteoblasts Mediated by Ca2+ Channels
Non-genomic action 1α 25-dihydroxyvitamin D3 Osteoblasts
2011/6/10
The biologically active form of vitamin D, 1α,25-dihydroxy vitamin D3 (VD), regulates the synthesis of the bone Ca-binding proteins osteocalcin and osteopontin. The actions of VD are mediated through ...
Gene expression monitoring in osteoblasts on titanium coated with fibronectin-derived peptide
Osteoblast RGD peptide GeneChip
2009/9/11
Enhanced adhesion and migration of osteoblastic cells on titanium (Ti) surface is believed to increase the success rate of implant therapy. A GRGDSP peptide derived from fibronectin was coated on Ti s...
Mechanical Strains Induced in Osteoblasts by Use of Point Femtosecond Laser Targeting
Mechanical Strains Laser Targeting
2009/9/8
A study demonstrating how ultrafast laser radiation stimulates osteoblasts is presented. The study employed a custom made optical system that allowed for simultaneous confocal cell imaging and targete...