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2024年5月14日，动物研究所科学数据中心林聪田博士与中国科学院城市环境研究所黄乾生研究员团队发挥各自数据优势，开展多学科数据交叉合作，共建“细胞外囊泡数据库”，相关数据论文成果以《EV-COMM: A database of interspecies and intercellular interactions mediated by extracellular vesicles》为题在细胞外...
苏州纳米所程国胜团队J Extracell Vesicles： Ang和TAT双肽修饰的工程化外泌体治疗脑胶质瘤的靶向递送策略（图）
程国胜 外泌体治疗 脑胶质瘤 靶向递送 生物毒性
2023/7/19
脑胶质瘤是指起源于脑神经胶质细胞的肿瘤，是最常见的原发性颅内肿瘤，我国脑胶质瘤年发病率为5~8/10万，五年病死率在全身肿瘤中仅次于胰腺癌和肺癌，这对人类生命健康产生巨大影响。目前，脑胶质瘤治疗以手术切除为主，但由于肿瘤的高侵袭性、快速生长和增强的血管生成，胶质瘤无法通过传统/常规手术进行干净切除，导致预后不良和生存时间短。针对有效抑制肿瘤生长和延长患者的生存期，化学药物疗法是结合手术切除治疗后最...
潘万龙博士开展学术讲座---《Mechanism used by HBV to hijack small extracellular vesicles and promote virus dissemination, infection, and replication》（图）
学术讲座 川北医学院 基础医学
2023/7/20
2022年4月28日下午，基础医学与法医学院邀请潘万龙博士在部门学术厅开展了题为“ Mechanism used by HBV to hijack small extracellular vesicles and promote virus dissemination, infection, and replication”的学术讲座。本校师生共三十余人参加了本次讲座。
近日，放射科裴贻刚副主任医师以共同第一作者在《Journal of extracellular vesicles 》(IF=14.976)发表了题为“Highly efficient magnetic labeling allows MRI tracking of the homing of stem cellderived extracellular vesicles following sys...
浙江大学基础医学院蔡志坚课题组在Journal of Extracellular Vesicles发文揭示载药红细胞来源的胞外囊泡在治疗肝脏相关疾病中具有巨大的应用前景（图）
浙江大学基础医学院 蔡志坚 Journal of Extracellular Vesicles 载药红细胞 胞外囊 治疗肝脏 应用前景
2020/12/15
胞外囊泡由于具有低免疫原性、低毒性、高度的生物兼容性、可自由穿越生物屏障、逃逸溶酶体介导的降解和可进行人工修饰等特点，是非常理想的药物输送载体。然而，要将胞外囊泡作为药物输送载体应用于临床仍面临着不少挑战，包括合适的胞外囊泡来源细胞、临床级别胞外囊泡的制备以及胞外囊泡对疾病组织的特异靶向性。红细胞来源的胞外囊泡作为药物输送载体具备许多天然的优势。因为，红细胞来源的胞外囊泡不含核及线粒体DNA，不涉...
中山大学医学院吴忠道教授团队关于日本血吸虫虫卵来源外泌体抑制肝纤维化的研究结果在Journal of Extracellular Vesicles发表（图）
中山大学医学院 吴忠道 日本血吸虫 虫卵来源 外泌体抑制 肝纤维化
2020/7/28
肝纤维化是所有慢性肝病的常见病理基础，也是慢性肝病发展为肝硬化、出现肝功能失调甚至肝癌必经阶段。因此，如何减缓或阻断肝纤维化进展具有重要的临床意义。近日，我校中山医学院吴忠道教授团队在日本血吸虫虫卵来源外泌体Sja-miR-71a在抑制血吸虫病引起的肝纤维化的研究中取得新进展，研究结果以研究长文（Article）形式发表在Journal of Extracellular Vesicles（中科院一...
四川大学华西基础医学与法医学院曾烨副研究员在Journal of Extracellular Vesicles上发表研究论文（图）
四川大学华西基础医学与法医学院 曾烨 副研究员 胞外囊泡 抗肿瘤 血管形成
2019/8/7
近日，四川大学华西基础医学与法医学院生物医学工程研究室曾烨副研究员团队在抗肿瘤血管形成研究方面取得突破性进展，相关研究成果“Anti-angiogenesis triggers exosomes release from endothelial cells to promote tumor vasculogenesis”发表于国际胞外囊泡协会（The International Society f...
The 2016 Gordon Research Conference titled "Extracellular Vesicles" will present cutting edge research on the molecular, cellular and clinical translational aspects of the structure and function of ex...
the 1st Cold Spring Harbor Asia conference on Biology & Function of Extracellular Vesicles: Exosomes, Microvesicles & Beyond
Microvesicles Beyond
2016/7/29
We are pleased to announce the 1st Cold Spring Harbor Asia conference on Biology & Function of Extracellular Vesicles: Exosomes, Microvesicles & Beyond which will be held in Suzhou, China, located app...
Covalent Attachment of Lipid Vesicles to a Fluid-Supported Bilayer Allows Observation of DNA-Mediated Vesicle Interactions
Caspian and Black Sea waters reverse-osmotic desalination Na-zeolite softening of the permeate
2016/5/25
Specific membrane interactions such as lipid vesicle docking and fusion can be mediated by synthetic DNA-lipid conjugates as a model for the protein-driven processes that are ubiquitous in biological ...
Kinetics of DNA-mediated Docking Reactions Between Vesicles Tethered To Supported Lipid Bilayers
DNA electron transfer oxidative stress redox regulation
2016/5/25
Membrane-membrane recognition and binding are crucial in many biological processes. We report an approach to studying the dynamics of such reactions by using DNA-tethered vesicles as a general scaffol...
Tension-Induced Pore Formation and Leakage in Adhering Vesicles
Tension-Induced Pore Adhering Vesicles
2016/5/24
The influence of inclusion-induced tension on pore formation is studied theoretically and experimentally. It is shown that fluorescently labeled lipids can enhance pore formation and induce leakage of...
Diffusive Dynamics of Vesicles Tethered to a Fluid Supported Bilayer by Single-Particle Tracking
Calcium Macromolecular Substances 4-Chloro-7-nitrobenzofurazan DNA Lipid Bilayers Phosphatidylcholines Coated Materials, Biocompatible Nucleic Acid Hybridization Fluorescence Recovery After Photobleaching Diffusion
2016/5/24
We recently introduced a method to tether intact phospholipid vesicles onto a fluid supported lipid bilayer using DNA hybridization (Yoshina-Ishii, C.; Miller, G. P.; Kraft, M. L; Kool, E. T.; Boxer, ...
Arrays of Mobile Tethered Vesicles on Supported Lipid Bilayers
Oligonucleotides,Antisense Lipid Bilayers Phosphatidylcholines Fluorescent Dyes Liposomes
2016/5/24
We report a new system of laterally mobile, arrayed vesicles that are encoded with DNA to control tethering to fluid-supported phospholipid bilayers. The motion of individual fluorescently labeled ves...
Androgen receptor distribution in the rat prostate gland and seminal vesicles
prostate seminal vesicle androgen receptor immunohistochemistry rat
2016/3/24
To better understand the effect of androgen on the growth and function of accessory sex glands, it can be useful to determine the presence or absence of the androgen receptor (AR) in the individual ce...