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中国科学院动物研究所专利：Fusion protein for inducing pluripotent stem cells and application method thereof
中国科学院动物研究所 专利 哺乳动物 YAP蛋白 转录控制活性
2024/5/31
提供了由哺乳动物YAP蛋白或具有转录控制活性的片段的融合蛋白的与细胞全能性和转录激活结构域相关的基因编码的蛋白、编码核苷酸序列、表达载体及其组合物，以及使用该融合蛋白诱导多能干细胞的方法。
中国科学院动物研究所专利：Delayed senescence, malignant conversion of human mesenchymal stem cells can be a resistor, its preparation and use
中国科学院动物研究所 专利 人骨髓间 充质干细胞
2024/5/30
延缓衰老，制备恶性人骨髓间充质干细胞的方法可抗选择性。 制备方法， 第二密码子的253个氨基酸残基的FOXO3蛋白， 丝氨酸密码子编码丙氨酸突变的密码子，FOXO3蛋白密码子的第315位氨基酸残基，丝氨酸密码子编码丙氨酸突变的密码子编码2个突变中的一个突变，编码多能干细胞的基因组包括该步骤。 制备的重组间充质干细胞，并进一步提供其在移植治疗中的用途。 [附图]
Covalent Self-labeling of Tagged Proteins with Chemical Fluorescent Dyes in BY-2 Cells and Arabidopsis Seedlings
BY-2 cells Arabidopsis SNAP-tag live cell imaging microtubules endocytosis PIN2 auxin transporter
2023/12/21
Synthetic chemical fluorescent dyes promise to be useful for many applications in biology. Covalent, targeted labeling, such as with a SNAP-tag, uses synthetic dyes to label specific proteins in vivo ...
Protein kinase sensors: an overview of new designs for visualizing kinase dynamics in single plant cells
plant cells protein kinase sensors kinase dynamics signaling networks SnRK2
2023/12/1
Protein kinase dynamics play key roles in regulation of cell differentiation, growth, development and in diverse cell signaling networks. Protein kinase sensors enable visualization of protein kinase ...
Cross-talk between clathrin-dependent post-Golgi trafficking and clathrin-mediated endocytosis in Arabidopsis root cells
Adaptor protein Arabidopsis TPLATE clathrin endocytosis exocytosis
2023/12/1
Coupling of post-Golgi and endocytic membrane transport ensures that the flow of materials to/from the plasma membrane (PM) is properly balanced. The mechanisms underlying the coordinated trafficking ...
Single-cell transcriptomics sheds light on the identity and metabolism of developing leaf cells
Single-cell transcriptomics photosynthetic Arabidopsis thaliana high-throughput transcriptome metabolic stress-related
2023/11/30
As the main photosynthetic instruments of vascular plants, leaves are crucial and complex plant organs. A strict organization of leaf mesophyll and epidermal cell layers orchestrates photosynthesis an...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：On the lowest two-sided cells of affine Weyl groups
仿射Weyl群 最低双侧胞 Kazhdan-Lusztig基
2023/12/11
In this talk, I will present a proof a decomposition formula of Kazhdan-Lusztig basis for the elements in the lowest two-sided cell of an affine Weyl group. This formula can be used to determine the l...
学术报告：IIIandMe: An Algorithm for Chromosome-scale Haplotype Determination Using Genome-wide Variants of Three Haploid Reproductive Cells
Algorithm Chromosome-scale Haplotype Determination
2023/7/20
贾震宇教授，本科就读于武汉大学生命科学学院生物化学专业。2006年于加州大学河滨分校同时取得统计学硕士和遗传-基因组-生物信息联合学科博士。先后就职于加州大学尔湾分校病理系、阿克伦大学统计系和俄亥俄西北医科大学医学系，从事包括前列腺癌在内的多种疾病的研究以及在生物统计和生物信息学科的教学工作。现受聘为加州大学河滨分校植物科学系数量遗传学教授。贾老师目前的研究工作包括基因组选择方法在作物育种和癌症预...
Engineers devise a way to selectively turn on RNA therapies in human cells（图）
人类细胞 RNA疗法 治疗性蛋白质 癌症治疗
2023/6/21
Researchers at MIT and Harvard University have designed a way to selectively turn on gene therapies in target cells, including human cells. Their technology can detect specific messenger RNA sequences...
Academy of Mathematics and Systems Science, CAS Colloquia & Seminars：Chevalley formulae for the motivic Chern classes of the Schubert cells
舒伯特 细胞动机陈类 切瓦利公式
2023/4/14
The motivic Chern classes of the Schubert cells are the K-theoretic generalizations of the Chern-Schwartz-MacPherson classes in homology. I will report some joint work in progress with L. Mihalcea and...
Different cell types—say, heart, liver, blood, and sperm cells—possess characteristics that help them carry out their unique jobs in the body. In general, those characteristics are hard-wired. Without...
A typical bacterial genome contains more than 4,000 genes, which encode all of the proteins that the cells need to survive. How do cells know just how much of each protein they need for their everyday...
New CRISPR-based tool inserts large DNA sequences at desired sites in cells（图）
CRISPR 新型工具 大DNA序列 PAST 基因工程
2023/6/21
Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.
中国科学院武汉植物园应邀在Cells上发表研究综述（图）
病原菌胁迫 生理生化 营养物质
2022/10/26
果实成熟，是指经过一系列生理生化变化而达到最佳食用状态的过程，是果实品质形成的必要前提。然而，随着果实成熟，其对病原菌的抗性也显著降低，导致一系列采后病害的发生，造成巨大的经济损失。传统贮藏保鲜技术通常需要抑制或延缓成熟进程，以牺牲成熟品质为代价，获得较长的货架期，这也导致果实风味和营养物质的严重丧失。因此，如何在有效维持果实成熟品质的同时，增强其对病原菌的抗性是采后生物学研究的重要课题。
In a single day, enough sunlight strikes Earth to power the world for an entire year—that is, if we can find a way to capture that energy cheaply and efficiently. While the cost of solar energy has de...