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A team at the Marine Biological Laboratory in Woods Hole, Massachusetts, has achieved the first gene knockout in a cephalopod using the squid Doryteuthis pealeii, an important research ...
Knockout of Myostatin by Zinc-finger Nuclease in Sheep Fibroblasts and Embryos
Myostatin Zinc-finger Nucleases Knockout, Sheep
2016/11/10
Myostatin (MSTN) can negatively regulate the growth and development of skeletal muscle, and natural mutations can cause “double-muscling” trait in animals. In order to block the inhibiting effect of M...
Differential Expression of Genes Important to Efferent Ductules Ion Homeostasis across Postnatal Development in Estrogen Receptor-慣 Knockout and Wildtype Mice
P450 Aromatase Estrogen Epithelial Ion Transporters
2016/4/27
Our earlier studies showed that estrogen was involved in the regulation of fluid reabsorption in adult mouse efferent ductules (ED), through estrogen receptor (ER) ??and ER?? by modulating gene expres...
Characterization of the Mitochondrial Proteome in Pyruvate Dehydrogenase Kinase 4 Wild-Type and Knockout Mice
Starvation Mitochondria Proteomics PDK4
2015/5/25
The goal of this study was to determine the effect of a PDK4 (pyruvate dehydrogenase kinase isoenzyme 4) knock-out on mitochondrial protein expression. A 2-D gel based mass spectrometry approach was u...
mGluR5 Knockout mice exhibit normal conditioned place-preference to cocaine
mGluR5 Knockout mice normal conditioned place-preference cocaine Neurons and Cognition
2012/4/28
Metabotropic glutamate receptor 5 (mGluR5) null mutant (-/-) mice have been reported to totally lack the rein- forcing or locomotor stimulating effects of cocaine. We tested mGluR5 -/- and +/+ mice fo...
Acquisition of Avoidance Responding in the Fmr1 Knockout Mouse
Fragile X Syndrome Fmr1 Knockout Active Avoidance
2013/2/23
Fragile X Syndrome (FXS) is the most common inherited cause of mental retardation. Much work has been done characterizing the behavioral phenotype of the animal model of FXS, the Fmr1 knockout mouse. ...
改进的Knockout自然景物提取算法
蓝屏景物提取 自然景物提取 透明度( 值)
2009/8/20
针对Knockout算法中颜色估计模型只适用于光滑图像的问题，提出一种新的颜色估计模型。采用区域生长法将未知区域划分为若干个子区域，以距离每一个子区域最近的前景和背景轮廓线上的点为中心做矩形块，分别计算2个矩形块内前景和背景像素点的颜色加权平均值，将其作为该子区域的前景和背景颜色分量。实验结果表明，改进后的颜色估计模型在图像边缘附近颜色相差较大的自然景物提取中有较好表现。
Medial Expression of TNF-α and TNF Receptors Precedes the Development of Atherosclerotic Lesions in Apolipoprotein E/LDL Receptor Double Knockout Mice
atherosclerosis lipoproteins TNF-α TNF receptors
2009/4/20
TNF-α is present in atherosclerotic lesions, activates endothelial adhesion molecule expression, stimulates the release of proinflammatory cytokines and matrix metalloproteinases and promotes smooth ...
Enhanced Goblet Cell Hyperplasia in HDC Knockout Mice with Allergic Airway Inflammation
airway remodeling asthma Gob-5 MUC5AC TNF-α
2010/11/16
The number of eosinophils in BALF increased in both the sensitized wild-type mice and Hdc-/- mice with OVA inhalation. In addition, the numbers of alveolar macrophages and lymphocytes in BALF increase...
Characterization of the fertility of male aromatase knockout mice
Estrogen spermatogenesis sexual behavior
2008/12/29
Previous studies employing the male aromatase knockout (ArKO) mouse have indicated that local expression of estrogens appears to be important for the progression of spermatogenesis. In the absence o...
Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice
Morphologic changes efferent ductules epididymis estrogen receptor-alpha
2008/12/25
Estrogen has been shown to have an important role in fluid reabsorption in efferent ductules of the testis. Our previous study of the estrogen receptor-alpha knockout mouse (ERKO) showed that the ...
Prolonged Histamine Deficiency in Histidine Decarboxylase Gene Knockout Mice Affects Leydig Cell Function
Steroidogenesis human choriogonadotropin
2008/12/24
The present study focuses on histaminergic regulation of Leydig cell physiology, since limited information is available so far. To evaluate the dependency of Leydig cells on histamine (HA), we pe...
Changes During Epididymal Maturation, Effects of pH, Osmotic Pressure, and Knockout of the c-ros Gene
Photobleaching analysis lipid dynamics fertilizing capacity germ cells
2008/12/3
It is well known that the plasma membranes of mammalian spermatozoa undergo extensive remodeling during maturation in the epididymal duct. In this investigation, we have used fluorescence recovery a...
期刊信息
篇名
Chemical kindling induced by pentylenetetrazol in histamine H1 receptor gene knockout mice (H1KO), histidine decarboxylase-deficient mice (HDC-/-) and mast cell-deficient W/Wv mice.
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英文
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