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The approach of exploiting highly conserved protein folds and structure in understanding protein function and in designing drugs leads to drugs that are less selective due to association with similar ...
MoRFs A Dataset of Molecular Recognition Features
protein-protein interactions intrinsic protein disorder bioinformatics
2015/5/26
The last decade has witnessed numerous proteomic studies which have predicted and successfully confirmed the existence of extended structurally flexible regions in protein molecules. Parallel to these...
Intrinsically disordered proteins in molecular recognition and structural proteomics
Protein function Protein structure Protein interactions
2015/5/26
Intrinsically disordered proteins (IDPs) are abundant in nature, being more prevalent in the proteomes of eukaryotes than those of bacteria or archaea. As introduced in Chapter I, these proteins, or p...
Protein function prediction by integrating sequence, structure and binding affinity information
protein function binding affinity information
2015/5/26
Proteins are nano-machines that work inside every living organism. Functional disruption of one or several proteins is the cause for many diseases. However, the functions for most proteins are yet to ...
Prediction by Partial Matching for Identification of Biological Entities
Identification Partial Matching Prediction
2015/5/26
As biomedical research and advances in biotechnology generate expansive datasets, the need to process this data into information has grown simultaneously. Specifically, recognizing and extracting thes...
INTRINSIC DISORDER AND PROTEIN EVOLUTION:
Amino Acid Composition Protein Evolution Intrinsic Disorder
2015/5/26
All twenty amino acids did not appear simultaneously in nature. Instead some of them appeared early, while others were added into the genetic code later. The amino acids that were formed by Miller (19...
System biology modeling : the insights for computational drug discovery
Drug Repositioning Machine Learning Side Effect
2015/5/26
Traditional treatment strategy development for diseases involves the identification of target proteins related to disease states, and the interference of these proteins with drug molecules. Computatio...
Context specific text mining for annotating protein interactions with experimental evidence
Systems biology Methodology
2015/5/26
Proteins are the building blocks in a biological system. They interact with other proteins to make unique biological phenomenon. Protein-protein interactions play a valuable role in understanding the ...
A Novel Network Biology Approach To Drug Target Selections
Network Biology Approach Drug Target Selections
2015/5/26
Conventional drug discovery focuses on single protein targets and follows a “sequence,
structure, and function” paradigm for selecting best protein targets to screen lead
chemical compounds. This es...
Protein Fold Recognition Using Adaboost Learning Strategy
Recognition Learning Strategy Protein Fold
2015/5/26
Protein structure prediction is one of the most important and difficult problems in computational molecular biology. Unlike sequence-only comparison, protein fold recognition based on machine learning...
Development and Application of a Mass Spectrometry-Based Quantitative Assay for Apolipoprotein M in Human and Mouse Serum
Mass Spectrometry Cholesterol Apolipoprotein M MS-Based Assay
2015/5/26
Apolipoprotein M (apoM) is necessary for the formation of lipid-poor preβ-HDL particles, the initial precursor of HDL and acceptors of cholesterol efflux from peripheral cells. An assay to quantify ap...
Metnase is a novel bifunctional protein that contains a SET domain and a transposase domain. Metnase contains sequence-specific DNA binding activity and sequence non-specific DNA cleavage activity, as...
Effect of Inhibition of S-Nitrosoglutathione Reductase on the NF-κB Pathway
I kappa B I kappa B kinase beta NF-kappa B
2015/5/25
S-nitrosoglutathione reductase (GSNOR) also known as glutathione- dependent formaldehyde dehydrogenase (FDH), is a zinc-dependent dehydrogenase. GSNOR oxidizes long chain alcohols to an aldehyde with ...
Regulation of Exocytosis by Syntaxin 4-Munc18c Complexes
Munc18c Syntaxin 4 SNARE diabetes
2015/5/25
Type 2 diabetes involves defects in glucose-stimulated insulin secretion (GSIS) from the pancreatic beta cells in combination with defects in peripheral (muscle and adipose) tissue glucose uptake. Bot...
MEMBRANE CHOLESTEROL BALANCE IN EXERCISE AND INSULIN RESISTANCE
Glucose Musculoskeletal system
2015/5/25
Study has shown that plasma membrane (PM) cholesterol and cortical filamentous actin (F-actin) influence skeletal muscle glucose transport. Of fundamental and clinical interest is whether diabetogenic...