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STRUCTURE-FUNCTION ANALYSIS OF CXXC FINGER PROTEIN 1
differentiation CXXC finger protein 1 histone methylation
2015/5/25
This dissertation describes structure-function studies of CXXC finger protein 1 (Cfp1), encoded by the CXXC1 gene, in order to determine the functional significance of Cfp1 protein domains and propert...
The MDM2-p53 feedback loop is a well-characterized pathway. p53 is a
transcription factor and regulates the transcriptional expression of genes that
encode proteins responsible for cellular senescen...
ELUCIDATING THE ROLE OF REDOX EFFECTS AND THE KU80 C-TERMINAL REGION IN THE REGULATION OF THE HUMAN DNA REPAIR PROTEIN KU
DNA-PKcs regulation Ku NHEJ
2015/5/25
DNA double strand breaks (DSB) are among the most lethal forms of DNA damage and can occur as a result of ionizing radiation (IR), radiomimetic agents, endogenous DNA-damaging agents, etc. If left unr...
STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1: A NOVEL PARTICIPANT IN GLYCOGEN METABOLISM
autophagy GABARAPL1 AIM/LIR
2015/5/25
Glycogen, a branched polymer of glucose, acts as an intracellular carbon and energy reserve in many tissues and cell types. The breakdown of glycogen by hormonally regulated degradation involving the ...
PURIFICATION OF SIMPL ANTIBODY AND IMMUNOFLUORESCENCE OF SIMPL SUB-CELLULAR LOCALIZATION IN RESPONSE TO TNFα- AND IL-1
SIMPL Transcriptional Co-Activator NF-kB
2015/5/25
SIMPL is a transcriptional co-activator that alters the activity of transcription factor, NF-κB. In response to pathogens, cytokines such as Interleukin-1 (IL-1) and Tumor Necrosis Factor (TNF) signal...
Determining molecular mechanisms of DNA Non-Homologous End Joining proteins
DNA repair non-homologous end joining
2015/5/25
DNA double strand breaks (DSB), particularly those induced by ionizing radiation (IR) are complex lesions and if not repaired, these breaks can lead to genomic instability, chromosomal abnormalities a...
Phospho-regulation and metastatic potential of Murine Double Minute 2
Metastasis Phosphorylation c-Src
2015/5/25
Murine double minute (Mdm2) is a highly modified and multi-faceted protein that is overexpressed in numerous human malignancies. It engages in many cellular activities and is essential for development...
Analysis of Histone Lysine Methylation Using Mass Spectrometry
MudPIT histones transcription
2015/5/25
Histones are highly basic proteins which when digested by trypsin are hard to analyze using mass spectrometry. Because histones are basic nuclear proteins, a nuclei prep followed by acid extraction is...
Mechanisms of recruitment of the CTD phosphatase Rtr1 to RNA polymerase II
Rtr1 RNA polymerase II transcription
2015/5/25
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit Rpb1 must exist in a hypophosphorylated state prior to forming a competent transcription initiation complex. However, during trans...
Investigation of the action of phosphatase of regenerating liver on PTEN using murine models
Phosphatase of Regenerating Liver PTEN Mouse Models
2015/5/25
The addition and removal of phosphate groups is a key regulatory mechanism for many cellular processes. The balance between phosphorylation and dephosphorylation is delicate and must be maintained in ...
Patients with the genetic disorder tuberous sclerosis complex (TSC) suffer from neoplastic growths in multiple organ systems. These growths are the result of inactivating mutations in either the TSC1 ...
The role of the CTD phosphatase Rrt1 and post-translational modifications in regulation of RNA polymerase II
CTD phosphatase Rtr1 MuDPIT AP-MS
2015/5/25
RNA polymerase II (RNAPII) is regulated by multiple modifications to the C-terminal domain (CTD) of the largest subunit, Rpb1. This study has focused on the relationship between hyperphosphorylation o...
Mechanisms of binding diversity in protein disorder : molecular recognition features mediating protein interaction networks
Many-to-one binding Partner selection MoRF
2015/5/25
Intrinsically disordered proteins are proteins characterized by lack of stable tertiary structures under physiological conditions. Evidence shows that disordered proteins are not only highly involved ...
The role of acid sphingomyelinase in autophagy
sensing rapamycin mammalian target of rapamycin
2015/5/25
Phosphatases of regenerating liver, consisting of PRL-1, PRL-2 and PRL-3, belong to a novel protein tyrosine phosphatases subfamily, whose overexpression promotes cell proliferation, migration and inv...
Optimizing hydropathy scale to improve IDP prediction and characterizing IDPs' functions
Intrinsically disordered proteins Support vector machine Clustering
2015/5/25
Intrinsically disordered proteins (IDPs) are flexible proteins without defined 3D structures. Studies show that IDPs are abundant in nature and actively involved in numerous biological processes. Two ...