搜索结果: 16-30 共查到“知识库 医学遗传学”相关记录1117条 . 查询时间(2.209 秒)
探讨心外膜脂肪组织(EAT)厚度、血清缺血修饰白蛋白(IMA)和高敏肌钙蛋白T(hs-cTnT)与急性冠状动脉综合征(ACS)的相关性。方法 选择2014年9月至2015年11月我院收治的120例ACS患者作为病例组,其中单支病变组、双支病变组和多支病变组各40例。选择同期在我院进行体检的心功能正常健康者120例作为正常对照组,采用超声心动图测定EAT厚度,采用白蛋白-钴离子结合试验法测定血清IM...
利用线粒体细胞色素C氧化酶亚基Ⅰ（COⅠ）基因对我国黑龙江省绥芬河、吉林省延边口岸全沟硬蜱的COⅠ基因序列和国外全沟硬蜱COⅠ序列进行分析对比研究，为了解蜱媒病及其防控奠定基础。方法 2013年6月至2016年8月从黑龙江省绥芬河口岸和吉林省延边口岸共采集全沟硬蜱106只，选取31只样本提取基因组DNA，采用PCR方法从蜱基因组中扩增COⅠ基因进行同源性分析，然后构建系统发生树，并对2个地理种群的...
糖尿病发病的表观遗传学机制
表观遗传学 DNA甲基化 组蛋白翻译后修饰 非编码RNA
2018/10/16
目前表观遗传通过DNA的甲基化、组蛋白的乙酰化、甲基化和非编码RNA的方式影响着生命的活动,表观遗传的变化会影响糖尿病及糖尿病并发症的发生和发展,研究表明,怀孕期间,各个基因的DNA甲基化异常,婴儿成年后得糖尿病的概率增加。在成人体内,DNA甲基化异常通过干扰胰岛的发育和影响胰岛的分泌,以及糖脂代谢的紊乱从而导致糖尿病。组蛋白的翻译后修饰主要分为:组蛋白的甲基化和乙酰化,主要通过作用于促炎症因子和...
Gene Expression Profiles of BAD and Bcl-xL in the CA1 Region of the Hippocampus Following Global Ischemic/Reperfusion and FK-506 Administration
Ischemic/Reperfusion Real-Time RT-PCR Hippocampus Tacrolimus Bcl-xL Gene BAD
2015/12/29
Background: The hippocampus is a tiny nub in the mammalian brain that is involved in forming, organizing, and storing memories. Global cerebral ischemia (GCI) and reperfusion induced apoptosis lead to...
Simulation of a classical swine fever outbreak in rural areas of the Republic of Serbia
Monte Carlo simulation classical swine fever
2015/11/26
Several different strategies for control and eradication of classical swine fever (CSF) were compared
using a Monte Carlo method-based simulation model.
HER2/neu和基于HER2/neu乳腺癌治疗的研究进展
HER2/neu 乳腺癌 表皮生长因子受体 单克隆抗体
2018/7/20
HER2/neu是表皮生长因子受体家族的一个成员,该基因的扩增或过表达在近30%的乳腺癌的发生发展和转移中起着重要的作用,也是乳腺癌预后判断的一个重要的生物标志物、更是乳腺癌分子靶向治疗的一个重要靶标。近年来,针对HER2/neu蛋白已经研制出了多种有效的药物,最主要的和已经进入临床应用的是针对HER2/neu蛋白的单克隆抗体类药物。HER2/neu阳性的乳腺癌经联合治疗后,85%的患者的存活期可...
Informatics Approaches to Linking Mutations to Biological Pathways, Networks and Clinical Data
Networks Linking Mutations Biological Pathways
2015/5/26
The information gained from sequencing of the human genome has begun to transform human biology and genetic medicine. The discovery of functionally important genetic variation lies at the heart of the...
Persistence of Students in RNBS Completion Online Programs
RNBSN Nursing online Nursing education
2015/1/19
The nursing shortage has reached unprecedented levels in the United States. In a response to meet current educational needs and demands to recruit, retain, and expand enrollment of students in baccala...
The Everyday Lives of Adolescent Girls with Epilepsy: A Qualitative Description
qualitative research stigma adolescent epilepsy
2015/1/19
This study is a qualitative description of the everyday lives of adolescent
girls with epilepsy. The primary purpose of the research was to determine
whether or not elements of stigma were present i...
Adolescent Birth Mothers After Unintended Pregnancy and Infant Open Adoption
biological mothers research qualitative research naturalistic inquiry
2015/1/19
Birth mothers of open adoption are not well studied. This inquiry explored birth mothers’ experiences surrounding unintended pregnancy and infant open adoption placement. The focused objective was to ...
EGFR基因突变状态未知NSCLC治疗
__TKI还是化疗？
肺肿瘤 EGFR基因状态未知 EGFR-TKIs 化疗
2014/10/27
目前对于表皮生长因子受体（epidermal growth factor receptor, EGFR）基因状态明确的非小细胞肺癌患者，其治疗推荐已成共识：对EGFR基因突变患者，可优先选择表皮生长因子受体酪氨酸激酶抑制剂（epidermal growth factor receptor-tyrosine kinase inhibitors, EGFR-TKIs），其治疗可最大获益；EGFR基因野...
The Association of Coagulation Factor V (Leiden) and Factor II (Prothrombin) Mutations With Stroke
Stroke Population Incidence
2015/10/15
Background: Epidemiological studies indicate that over the past forty years, the stroke incidence rates has increased. Factors V and II mutations are established genetic-variant risk factors for venou...
Comparison of Plasma Oxidative Biomarkers and Conformational Modifications of Hemoglobin in Patients With Diabetes on Hemodialysis
Hemodialysis Hemoglobin Oxidative Stress Plasma
2015/10/15
Background: Diabetes is associated with an increased generation of reactive oxygen species (ROS), which plays an important role in the development of oxidative stress and anemia.
Single-Nucleotide Polymorphisms Within MicroRNAs Sequences and Their 3' UTR Target Sites May Regulate Gene Expression in Gastrointestinal Tract Cancers
MicroRNAs Gastrointestinal Neoplasms Colorectal Neoplasms Gastric Neoplasms
2015/10/13
Background: Esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (GIT) neoplasms, causing almost two million deaths worldwide each year. some environmental risk facto...