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SO2衍生物通过NLRP3炎症小体促进气道上皮细胞炎症发生
SO2衍生物 NLRP3炎症小体 气道炎症 活性氧簇
2020/9/15
观察二氧化硫（SO2）衍生物亚硫酸钠和亚硫酸氢钠对支气管上皮细胞NLRP3炎症小体活化的影响。方法：使用不同浓度的SO2衍生物作用于支气管上皮细胞16HBE，通过流式细胞术检测细胞内活性氧簇（ROS）的生成，Western blot检测细胞内NLRP3和caspase-1 p20蛋白水平，ELISA检测细胞上清中白细胞介素1β（IL-1β）的分泌水平，结合细胞毒性实验（MTT）确定2 mmol/L...
超高效液相色谱法快速测定人血浆中替考拉宁的浓度及其应用
替考拉宁 超高效液相色谱法 二极管阵列检测器 血浆浓度
2020/9/1
建立超高效液相色谱法(UPLC)快速测定人血浆中替考拉宁的浓度。方法 分析色谱柱为Acquity UPLC BEH-C18(2.1 mm×50 mm,1.7 μm)。流动相A为含20 mmol·L-1乙酸铵的超纯水,流动相B为乙腈。柱温35 ℃。流速为0.5 mL·min-1,梯度洗脱。检测波长为215 nm。用哌拉西林钠为内标。采用SPSS对内标法和外标法的计算结果进行配对t检验,以考察两种计算...
社会平均工资水平与“药占比”的相关性研究
药占比 药品费用 社会平均工资
2020/9/1
探讨社会平均工资对“药占比”的影响,为我国监测和管理“药占比”,合理控制药品费用提供支持。方法 基于经济合作与发展组织数据库,采用2006~2015年24个经济合作与发展组织(OECD)欧洲国家的年度“药占比”数据以及社会年平均工资数据,描述性分析“药占比”随时间和年平均工资的变化趋势;采用15个欧元区国家2006~2015年数据构建面板数据计量模型,分析年平均工资和时间与“药占比”的相关性。
目的 研究蒲葵子总黄酮（total flavonoids of Fructus Livistonae，TFFL）对对乙酰氨基酚（acetaminophen，APAP）诱导的人正常肝细胞LO2损伤的作用，初步探究TFFL保护肝损伤的作用机制。方法 MTT法考察TFFL对LO2细胞的毒性及对APAP诱导的LO2细胞存活率的影响；流式细胞术和Hoechst 33342染色法考察LO2细胞凋亡率；试剂盒检...
青蒿素类药物走向世界的序曲（图）
青蒿素 青蒿素类药物 世界卫生组织 国际合作
2019/11/21
本文介绍了中国科学家与世界卫生组织合作研制青蒿素类药物的曲折历史。中国科学家从药用植物中发现青蒿素并对其进行结构改造后，将各种高效、速效的青蒿素衍生物向国际公开，寻求国际合作以造福更多疟疾患者。为什么这项国际合作没有能够成功，其中有科技体制方面的问题，但更多的是中国自身产业化能力的缺失以及对某些问题的重视程度不够。通过分析这段历史的经验教训，希望能够为以后中国药物研发之路提供一些借鉴。
183例突发性聋患者焦虑抑郁状况分析
突发性聋 焦虑 抑郁
2018/5/23
分析突发性聋患者焦虑抑郁的发生情况及其影响因素,为临床辅助治疗提供参考依据。方法 使用汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)及耳鸣残疾量表(THI),对突发性聋患者进行评估,并以健康且听力正常志愿者作为对照组,探究突发性聋患者发生焦虑抑郁情况、产生原因,及焦虑抑郁状态对疗效的影响。结果 实验组焦虑抑郁得分分别为(7.71±4.92,8.86±7.05),与对照组(4.00±2....
A Meta-Analysis of Randomized Clinical Trials Comparing Shorter (Less or Equal Than 6 Months) and Longer (More or Equal Than 12 Months) Dual Anti-Platelet Therapy Following Drug-Eluting Coronary Stents
Drug-Eluting Stents Dual Antiplatelet Therapy Meta-Analysis
2015/11/9
Context: The optimal duration of dual anti-platelet therapy (DAPT) after the implantation of drug-eluting coronary stents (DES) is still the subject of ongoing debate. This meta-analysis was performed...
探讨氯碘羟喹(CQ)联合锌离子(zinc)对人宫颈癌HeLa细胞系的放射增敏作用。方法 将细胞分为对照组、药物组、单纯照射组、药物+照射组。CCK-8法检测不同浓度氯碘羟喹联合锌离子对HeLa细胞的毒性作用;集落形成实验检测氯碘羟喹联合锌离子对HeLa细胞放射敏感性的影响,依据单击多靶模型拟合剂量-生存曲线,并计算放射增敏参数;流式细胞仪检测HeLa细胞周期与凋亡率;单荧光素酶报告基因法检测核转录...
Analgesic efficacy of orally administered buprenorphine in rats:methodologic considerations
buprenorphine analgesia rat pain strain flavor aversion pica
2015/7/30
Buprenorphine has been widely recommended for treatment of pain in rodents. We have previously documented that the recommended postoperative oral dose of buprenorphine in male Long-Evans rats, 0.5 mg/...
Flipping Content to Improve Student Examination Performance in a Pharmacogenomics Course
active learning process-oriented guided inquiry learning instructional design
2018/9/4
Objective. To develop, implement, and evaluate active learning in a flipped class to improve student examination performance in the genetic foundations of pharmacogenomics.
Design. The flipped classr...
Simulated Order Verification and Medication Reconciliation during an Introductory Pharmacy Practice Experience
electronic health record simulation introductory pharmacy practice experience
2018/9/4
Objective. To create, implement, and assess a simulated medication reconciliation and an order verification activity using hospital training software.
Design. A simulated patient with medication orde...
Evaluating the Effects of Flexible Learning about Aseptic Compounding on First-year Students in a Pharmacy Skills Laboratory
flexible learning aseptic compounding assessment confidence
2018/9/4
Objective. To evaluate how flexible learning via online video review affects the ability and confidence of first-year (P1) pharmacy students to accurately compound aseptic preparations.
Design. Custo...
Using the Jigsaw Technique to Teach Clinical Controversy in a Clinical Skills Course
jigsaw clinical controversy
2018/9/4
Objective. To evaluate the effectiveness and student perception of the jigsaw technique to engage students in a clinical controversy exercise and to assess student engagement level during each step of...
Enhancing Academic Success by Creating a Community of Learners
academic success learning community
2018/8/21
Objective. To enhance academic performance and student progression by creating a community of learners.
Design. Academic performance and student progression of students participating in the first 3 y...
A Required Online Course with a Public Health Focus for Third Professional Year Pharmacy Students
Public health online learning self-directed learning instructional technology wiki
2018/8/21
Objective. To design, deliver, and evaluate the impact of a required course on student knowledge acquisition and ability to evaluate contemporary public health issues.
Design. A 2-credit course was i...