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Development of male urogenital epithelia elicited by soluble mesenchymal factors
male urogenital epithelia soluble mesenchymal factors
2009/2/13
Androgen-dependent development of male secondary sexual glands is mediated by paracrine mesenchymal-epithelial interactions that regulate a complex array of biological events such as epithelial mo...
The contraceptive effects of etoprine on male mice and rats
Etoprine male contraception spermatogenesis dihydrofolate reductase
2009/2/13
We had previously found that 2,4-diaminopyrimidines affected spermatogenesis, possibly through the inhibition of testicular dihydrofolate reductase (DHFR). The current study examined the effects of ...
Secretory leucocyte protease inhibitor in the male genital tract：PSA-induced proteolytic processing in human semen and tissue localization
Protease inhibitors proteolytic enzymes prostate semen seminal vesicles
2009/2/13
Secretory leucocyte protease inhibitor, SLPI, is a low-molecular-weight, acid-stable protein present in the liquid part of fresh human ejaculate but not demonstrable in the gel structure. No fragm...
Acute immobilization stress disrupts testicular steroidogenesis in adult male rats by inhibiting the activities of 17 alpha-hydroxylase and 17,20-lyase without affecting the binding of LH/hCG receptors
Stress rats testosterone 17a-hydroxylase
2009/2/12
We have investigated the effect of acute immobilization (3 hours) stress on testicular steroidogenesis in the adult rat. Immobilization did not alter plasma luteizing hormone (LH) levels, but plas...
Effects of castration and recombinant human inhibin administration on circulating levels of inhibin and gonadotropins in adult male monkeys
castration recombinant human inhibin administration circulating levels inhibin gonadotropins adult male monkeys
2009/2/12
Inhibin has been suggested to play a role in gonadal feedback regulation of follicle-stimulating hormone (FSH) secretion; however, neither the half-life nor the time course of action of recombinan...
The effects of chronic administration of pyrimethamine on spermatogenesis and fertility in male rats
Spermatogenesis fertility pyrimethamine testes cytotoxic
2009/2/12
The present study examines whether the antifertility effects of pyrimethamine (PYR), an inhibitor of dihydrofolate reductase, are mediated by a reduction in intratesticular testosterone (T) concentr...
Recovery of pituitary-gonadal function in male rats after long-term suppression induced by a single injection of microcapsules of LH-RH antagonist cetrorelix（SB-75）
Reversible gonadal inhibition cancer contraception
2009/2/12
The clinical utility of luteinizing hormone-releasing hormone (LH-RH) analogs can be greatly enhanced by a sustained delivery system, which could maintain elevated peptide levels in the blood for ...
Pharmacokinetics and pharmacodynamics of a parenteral testosterone microsphere formulation in the male rat. Demonstration of dose dependence and controlled release
Testosterone microsphere formulation androgen delivery methods testosterone effects on LH, FSH, and accessory sex organs rat
2009/2/11
This study examined the pharmacokinetics (the time course and pattern of testosterone release) and pharmacodynamics (effects on accessory sex organ weights, and serum LH and FSH levels) of a biode...
Immunocytochemical localization of the Yf subunit of glutathione S-transferase P shows regional variation in the staining of epithelial cells of the testis, efferent ducts, and epididymis of the male rat
Epididymis testis basal cells glutathione S-transferase detoxification
2009/2/11
Glutathione S-transferases (GSTs) are a family of isozymes that catalyze the conjugation of glutathione (GSH), a tripeptide found in all mammalian cells; this function plays a protective role, as th...
Acute and long-term effects of a single dose of the fungicide carbendazim（methyl 2-benzimidazole carbamate）on the male reproductive system in the rat
fungicide carbendazim（methyl 2-benzimidazole carbamate） male reproductive system rat
2009/2/11
The effects of carbendazim (methyl 2-benzimidazole carbamate) on the testis, efferent ductules, and sperm were determined in the adult rat after a single oral dose. Two experimental trials were perf...
Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors
urogenital development mesenchymal-epithelial interactions seminal vesicle prostate cancer keratinocyte growth fact
2009/2/11
Androgen-dependent male urogenital development occurs via mesenchymal-epithelial interactions in which mesenchyme induces epithelial morphogenesis, regulates epithelial proliferation, and evokes e...
The effect of ketoconazole on endocrine and reproductive parameters in male mice and rats
Ketoconazole male fertility male contraception testosterone corticosterone
2009/2/10
Ketoconazole has been shown to reduce steroidogenesis by inhibiting the cytochrome P-450 enzymes in these pathways. This finding, along with the observation that the compound reduces sperm motili...
Impact of clinically silent inflammation on male genital tract organs as reflected by biochemical markers in semen
granulocyte elastase fructose citric acid neutral aipha-glucosidase prostate function
2009/2/7
Three hundred eight-nine healthy, infertile patients were studied to determine the effects of inflammation on genital tract organs. Clinically silent inflammation was diagnosed by measuring polymo...
Assessment of the hypothalamic-pituitary-testicular function in male patients with Wilson's disease
Liver disease gonadotropins gonadotropinreleasing
2009/2/7
Sixteen male patients with Wilson's disease were studied to detect potential endocrine dysfunctions. There was no clinical evidence of feminization in any of the patients, and the patient group span...
Gonadotroph and Leydig cell responsiveness in the male rat. Effects of experimental left varicocele
Gonadotroph and Leydig cell responsiveness male rat experimental left varicocele
2009/2/6
Previous experiments have found that experimental left-sided varicocele (ELV) in rats is associated with significant bilateral reductions in intratesticular testosterone concentrations. The curren...