搜索结果: 16-21 共查到“医学 CD14”相关记录21条 . 查询时间(0.05 秒)
目的：探讨清肝活血方及其拆方对库普弗细胞（Kupffer cell, KC）表达CD14、Toll样受体4（Toll like receptor 4, TLR4）及核因子-κB (nuclear factor-κB, NF-κB)的影响。方法：原代分离大鼠KC，以一定剂量脂多糖（lipopolysaccharide, LPS）作用一定时间，加入一定浓度的清肝活血方及其拆方清肝方和活血方药物血清，W...
目的: 探讨清肝活血方及其拆方对酒精性肝病(alcoholic liver disease, ALD)大鼠肝组织CD14、TLR4表达的影响. 方法: ♂Wistar大鼠100只随机分成空白组、CCl4组各10只, 余80只为造模组, 采用复合因素复制ALD模型6 wk. CCl4组予微量CCl4腹腔注射, 每周2次. 造模4 wk后将模型组随机分成4组, 清肝活血方及其拆方组各15只, 余为模型...
重组抗人CD14单链抗体及其免疫毒素的研究
单链抗体 免疫毒素 重组抗人CD14
2008/6/24
单抗靶向治疗白血病具有独到优势。自制抗人CD14新克隆ZCH-7-2F9单抗具有识别AML-M5a的作用。该项目采用基因工程方法对2F9单抗重链和轻链可变区基因（VH2F9和VL2F9)进行克隆、测序并研制单链抗体，对其功能进行初步研究，为临床靶向治疗白血病提供新的试验制剂。结果表明2F9鼠Ig重链和轻链可变区基因分别为360bp和321bp，分别编码120和107个氨基酸。采用重叠延伸拚接等方法...
No Association of Polymorphisms in the 5' Region of the CD14 Gene and Food Allergy in a Japanese Population
5' region CD14 food allergy gene polymorphism
2010/11/18
Background: The gene encoding CD14 is a positional candidate gene for allergic diseases as it is localized on chromosome 5q31, a region that is linked to atopy-related phenotypes.
Although it has bee...
Failure to Find an Association between CD14-159C/T Polymorphism and Asthma: A Family-based Association Test and Meta-analysis
CD14 genetics haplotype polymorphism transmission disequilibrium test
2010/11/18
Background: CD14 is an essential component of the receptor for lipopolysaccharide (LPS) . LPS stimulates T-helper type 1 (Th1) cytokine expression, potentially suppressing Th2 immune responses involve...
Serum levels of soluble CD14 in allergic inflammation
asthma atopic dermatitis CD14 inflammation macrophage monocyte
2010/11/29
Monocytes/macrophages have recently been shown to play a significant role in the pathogenesis of allergic diseases. As the level of soluble CD14 (sCD14) in serum is considered a marker of monocyte/mac...