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Inhibitory effect of olopatadine hydrochloride (KW-4679), a novel antiallergic drug, on peptide leukotriene release from human eosinophils
antiallergic drug human eosinophils leukotriene olopatadine
2010/11/25
Olopatadine hydrochloride (olopatadine; KW-4679), (Z)-11-[(3-dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid monohydrochloride, is an antiallergic drug with selective and potent...
Invitro evaluation and optimization of controlled release floating drug delivery system of metformin hydrochloride
Invitro evaluation and optimization controlled release floating drug delivery system metformin hydrochloride
2010/2/8
The floating microspheres have been utilized to obtain prolonged and uniform release in the stomach for development of a once daily formulation. The major advantage of the preparation technique includ...
Formulation of an injectable implant for peptide delivery and mechanistic study of the effect of polymer molecular weight on its release behavior
Injectable implant Poly (lactide-co-glycolide) Molecular weight Release Erosion
2010/2/3
The effects of polymer molecular weight on drug release from erodible matrices are not well known. It would be more complicated for in-situ forming injectable implants that change gradually from liqui...
Role of protein kinase A in the inhibition of human mast cell histamine release by β-adrenergic receptor agonists
β-adrenergic receptor agonist histamine release human cultured mast cells protein kinase A protein kinase C
2010/11/24
Stimulation of mast cells induced the elevation of intracellular cytosolic free Ca2+ concentrations ([Ca2+]i) and the translocation of protein kinase C (PKC) from the cytosol to the cell membrane, fol...
An Investigation on Metallic Ion Release from Four Dental Casting Alloys
Corrosion Ion release Base metal alloys ICPAES Biocompatibility Dental alloys Nickel chromium alloys Cobalt chromium alloys
2010/2/5
Statement of Problem: Element release from dental casting alloys into the oral environment is of clinical concern and is considered to be a potential health problem to all patients. Purpose: The aim o...
Saiboku-to, a Kampo herbal medicine, inhibits LTC4 release from eosinophils
basophil bronchial asthma eosinophil Glycyrrhiza root LTC4 Saiboku-to
2010/11/29
Saiboku-to (TJ-96), a traditional Kampo herbal formation, has been used in the treatment of bronchial asthma in Japan as an anti-allergy herbal medicine. We investigated the effect of TJ-96 on leukotr...
Role of protein kinase C and calmodulin in histamine release in experimental filariasis
Brugia malayi calmodulin histamine lung mast cells Mastomys natalensis peritoneal mast cells protein kinase C
2010/11/29
The allergenic activity of 60 kDa antigen of Brugia malayi adult worm, due to its ability to release histamine from mast cells, has been previously reported by us. To determine the roles of protein ki...
An In-Vitro Study on the Release of Fluoride from Two Restorative Materials and Their Rechargeability after Exposure to Daily 1000 ppm Fluoride
Fluoride release Fluoride uptake Resin modified glass ionomer
2010/2/8
Statement of Problem: Since the fluoride releases from materials with the property of releasing fluoride are decreasing gradually, it seems that probably the material rechargeability is more important...
Effects of docosahexaenoic acid–rich n−3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study
PBMCs EPA
2016/12/30
Dietary fish or fish oil rich in n−3 fatty acids (n−3 FAs), eg, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), ameliorate inflammatory reactions by various mechanisms. Whereas...
In Vitro Release of Propranolol Hydrochloride from Topical Vehicles
Vitro Release Propranolol Hydrochloride Topical Vehicles
2016/3/10
Transdermal drug delivery is becoming increasingly important and for this reason it is clear that academia must ensure that current graduates are knowledgeable in all facets of topical drug administra...