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Structure, Function, and Pharmacological Chaperones for Human α-N-Acetylgalactosaminidase
Pure sciences Biological sciences Galactosidase Acetylgalactosaminidase Lysosomal storage disease Pharmacological chaperones Structural biology X-ray crystallography
2014/12/10
Human lysosomal α-N-acetylgalactosaminidase (α-NAGAL) is responsible for the break down of glycolipids and glycopeptides that contain a terminal α-linked N-acetylgalactosamine residues. Deficiency of ...
Pharmacological Chaperoning in Fabry Disease
Pharmacological Chaperone Fabry Disease X-ray Crystallography
2014/12/9
Fabry Disease is an X--‐linked lysosomal storage disorder characterized by a variety of symptoms including hypohydrosis, seizures, cardiac abnormalities, skin lesions, and chronic pain. These symptoms...
Triheterocyclic Thiadiazepine Derivatives of Pharmacological Interest: Synthesis of 2-Aryl-4-[p-(2,3-dihydro-5-methyl-2-oxo-1,3,4-oxadiazol-3-yl)phenyl]-6-(un)substituent-1
4-acetylphenylsydnone 1，3-dipolar cycloaddition 1，3，4-thiadiazepine 1，2，4-triazole 1，3，4-oxadiazo-line triheterocycle ring closure condensation Michael addition cardiovascular agent
2007/12/20
摘要 Synthesis of novel thiadiazepine derivatives based on the reactivity of 4-acetylphenylsydnone (1) was reported. The structures of the newly synthesized compounds have been proved by their physical,...
Synthesis and Pharmacological Activity of Annelated Pyrimidine Derivatives
2-methylsulfanylpyrimidine thienopyrimidine
2007/12/20
摘要 A series of 1-glycosyl-2-glycosylthiopyrimidine (4), annelated pyrimidinederivatives, pyrazolo[3,4-d]- pyrimidine (8), ditetrazolo[1,5-a;1',5'-c]pyrimidine (9), 2,9a,10-triazaanthracene (12), thien...
A Rapid and Convenient Synthetic Route to Novel 1,5-Benzodiazepine Derivatives of 5-Methyl-3-phenyl-2-oxo-Δ4-1,3,4-oxadiazolines from p-Acetylphenylsydnone and Their Pharmacological Activity
pp-acetylphenylsydnone 1 3-dipolar cycloaddition 1 5-diazepine Michael addition microw
2007/12/19
摘要 A simple and high yielding method for the integration of 1,5-benzodiazepines integrated with 5-methyl- 2-oxo-3-phenyl-Δ4-1,3,4-oxadiazolines in 75%—90% yield by microwave irradiation is devised. Mi...
期刊信息
篇名
In vitro pharmacological characterization of TKI-28, a broad-spectrum tyrosine kinase inhibitor with anti-tumor and anti-angiogenic effects.
语种
英文
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作者
Guo XN.,Zhong L.,Tan JZ.,Li J.,Lu...