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Synthesis and Biological Activity of Allosteric Modulators of GABAB Receptors. Part 4. Synthesis of Potentially Fluorescent Acridines and Conformationally Restricted N-(arylpropyl)-1-arylethylamines
Fendiline analogues acridines acridones aminotetralins aminoindanes GABA
2010/4/15
A series of 8 new derivatives of fendiline was prepared for evaluation as allosteric modulators of GABAB receptors: 4 based on acridine and 4 with restricted distance between the 2 aryl moieties.
Microwave-Assisted Synthesis of 1,4´-Diazaflavone and N-Alkyl Derivative Pigments with Anti-Microbial Activity
Microwave-assisted aza-chalcone 1,4' -diazaflavone N-alkyl-1,4' -diazaflavonium bromide anti-microbial activity pigment (3-12)
2010/4/16
1,4'-Diazaflavone pigment (2) was synthesized by a simple environmentally friendly microwave-assisted one-pot method for the cyclization of 2'-amino (E)-4''-aza-chalcone (1) under solventless conditio...
The Synthesis and Antimicrobial Activity of \\\g-Butyrolactone Derivatives
Btyrolactone derivatives antimicrobial activities
2010/4/16
This paper examines the synthesis of g-butyrolactone compounds 2, 3, 4, 5, and 9, and their potential antimicrobial nature and ability. The structures of all the compounds mentioned above were determi...
Synthesis and Antimicrobial Activity of Some 3(2H)-Pyridazinone and 1(2H)-Phthalazinone Derivatives
3(2H)-pyridazinone 1(2H)-phthalazinone antimicrobial activity
2010/4/16
Some 3(2H)-pyridazinone and 1(2H)-phthalazinone derivatives were synthesized. The structures of these new compounds were confirmed by IR, 1H-NMR, mass spectrum, and elemental analysis. The synthesized...
Efficient Synthesis of Imidazole Derivatives: An Important Synthon for the Preparation of Biologically Active Compounds
Imidazole N-chlorosuccinimide chloroimidazole chloroimidazole-carboxaldehyde
2010/4/16
4(5)-Chloro-imidazole-5(4)-carboxaldehyde derivatives are important precursors for the preparation of biologically active compounds. We developed a simple, novel, and efficient method for the synthesi...
Synthesis, Spectroscopic and Biological Investigation of Cyclic Octapeptide: Cherimolacyclopeptide G
Cyclic octapeptide cherimolacyclopeptide G antibacterial activity antifungal activity anthelmintic activity cytotoxicity
2010/4/16
A natural cyclic octapeptide cherimolacyclopeptide G (8) was synthesized by coupling of tetrapeptide units Boc-Gly-Ala-Val-Pro-OMe (5) and Boc-Ile-Tyr-Ala-Pro-OMe (6) after proper deprotection at carb...
Synthesis and Characterizations of Some New 4H-1,2,4-Triazole Derivatives
4H-1,2,4-triazole 1,3,4-thiadiazole 1,3-benzoxazole salicyl aldehyde acetylation acrylonitrile acrylic acid
2010/4/16
3-[(5-Amino-1,3,4-thiadiazol-2-yl)methyl]-4-ethoxycarbonylamino-5-alkyl-4H-1,2,4-triazoles (2a,b) were obtained from the reaction of 3-cyanomethyl-5-alkyl-4-ethoxycarbonylamino-4H-1,2,4-triazoles (1a...
Short and Effective Synthesis of a Thiophene Analogue of (\pm)-4-Ipomeanol and Its Biological Evaluation
Sonogashira reaction 4-ipomeanol cytotoxic activity MTT assay
2010/4/19
The thiophene analogue of (\pm)-4-ipomeanol (1) was prepared in 2 steps starting from 3-iodothiophene and pent-4-yn-2-ol. The key steps were a Sonogashira reaction, followed by HgO catalysed hydratisa...
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) as Donor Ligands in Organotin(IV) Derivatives: Synthesis, Spectroscopic Characterization and Biological Applications
Derivatives Synthesis Spectroscopic Characterization Biological Applications
2010/4/20
Some new di- and tri-organotin(IV) derivatives of 4 different non-steroidal anti-inflammatory drugs (NSAIDs) with the general formulae R2SnL2 and R3SnL (where R = n-C8H17 and C6H5CH2) and L = 2-[(2,3-...
Synthesis and Complex Formation of Some Novel vic-Dioxime Derivatives of Hydrazones
vic-Dioximes Glyoximes Hydrazone compounds Metal complexes
2010/4/20
Three novel vic-dioxime compounds and their transition metal complexes were synthesized for the first time. These ligands are anti-glyoximehydrazine (GH2), anti-2-pyridinealdehydeglyoxime hydrazone (P...
Direct Dyes Derived from 4,4'-Diaminobenzanilide Synthesis, Characterization and Toxicity Evaluation of a Disazo Symmetric Direct Dye
Direct dyes 4,4'-diaminobenzanilide fastness properties Hydractinia echinata toxicity MRC50
2010/4/20
The synthesis of a new symmetric disazo direct dye containing the non--carcinogenic 4,4'-diaminobenzanilide as the middle component and salicylic acid as the coupling component is presented. The synth...
Synthesis, Characterization and Biological Applications of Organotin(IV) Derivatives of 2-(2-Fluoro-4-biphenyl)propanoic Acid
Synthesis Characterization Biological 2-(2-Fluoro-4-biphenyl)propanoic Acid
2010/4/21
A series of organotin(IV) derivatives with the general formula R4 - nSnLn (where n = 1 or 2, R = Me, Et, n-Bu, Ph and L = 2-(2-fluoro-4-biphenyl)propanoate) have been synthesized and characterized by ...
Synthesis and Antimicrobial Testing of Some Flavonylsulfonamide Derivatives
Flavonylsulfonamides synthesis antimicrobial
2010/4/21
Six new 4-amino-N-heteroaryl,N-[(2-phenyl-4H-1-benzopyran-4- oxo-6-yl)metil]benzensulfonamide derivatives, (3a-3f) were prepared by reacting 6-bromomethylflavone with the corresponding sulfonamide der...
Trypsin-Catalyzed Peptide Synthesis in Acetonitrile with Low Water Content
Peptide synthesis trypsin immobilization organic solvent alumina
2010/4/22
Trypsin was immobilized to alumina by adsorption from its aqueous solutions. The activity of trypsin was increased by immobilization for peptide synthesis. With these immobilized enzymes Bz-Arg-Leu-NH...
Synthesis of azobenzo[b]thiophene derivatives and their dyeing performance on polyester fibre
Synthesis azobenzo[b]thiophene derivatives polyester fibre
2010/4/22
Ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate was synthesised by the reaction of cyclohexanone and sulphur with ethylcyanoacetate. The 2-aminothiophene derivative was diazotised and ...