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Structural and Spectroscopic Analysis of the Kinase Inhibitor Bosutinib and an Isomer of Bosutinib Binding to the Abl Tyrosine Kinase Domain
Humans Escherichia coli Benzamides Quinolines Nitriles Aniline Compounds Piperazines Pyrimidines Thiazoles Recombinant Proteins
2016/5/25
Chronic myeloid leukemia (CML) is caused by the kinase activity of the BCR-Abl fusion protein. The Abl inhibitors imatinib, nilotinib and dasatinib are currently used to treat CML, but resistance to t...
Spectroscopic Study of Ser92 Mutants of Human Myoglobin:Hydrogen Bonding Effect of Ser92 to Proximal His93 on Structure and Property of Myoglobin
Carbon Monoxide Cyanides Escherichia coli Ferric Compounds Ferrous Compounds Histidine Humans Hydrogen Bonding Magnetic Resonance Spectroscopy Mutagenesis Myoglobin Myoglobin Oxygen Polymerase Chain Reaction Recombinant Fusion Proteins Serine Serine Spectrophotometr Spectrum Analysis, Raman Structure-Activity Relationship
2016/5/23
Neutron diffraction studies have demonstrated that the hydroxyl group oxygen of Ser92(F7) is hydrogen bonded to the proximal His93(48) N epsilon H proton in myoglobin (Mb) [Cheng, X., & Shoenborn, B. ...
Spectroscopic and Redox Properties of Sym1 and (M)F195H Rhodobacter capsulatus Reaction Center Symmetry Mutants Which Affect the Initial Electron Donor
Circular Dichroism Electron Spin Resonance Spectroscopy Electron Transport Genes, Bacterial Kinetics Light-Harvesting Protein Complexes Mutation Oxidation-Reduction Photosynthetic Reaction Center Complex Proteins Plasmids Protein Conformation Rhodobacter capsulatus Spectrophotometry
2016/5/23
The redox properties, absorption, electroabsorption, CD, EPR, and P+QA- recombination kinetics have been measured for the special pairs of two mutants of Rhodobacter capsulatus reaction centers involv...
Picosecond Spectroscopic Study of Chlorophyll-Based Models for the Primary Photochemistry of Photosynthesis
Picosecond Spectroscopic Study Chlorophyll-Based Models Primary Photochemistry Photosynthesis
2016/5/20
A series of covalently linked dimers and trimers of chlorophyllide derivatives was investigated by time-resolved absorption and fluorescence spectroscopy (3-lo4 ps). For these compounds, the freeenerg...