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Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans
dietary protein protein source high-protein diet gut microbiota
2018/11/19
Background: Although high-protein diets (HPDs) are frequently consumed for body-weight control, little is known about the consequences for gut microbiota composition and metabolic activity and for lar...
Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: a randomized, parallel, double-blind trial in overweight humans
dietary protein protein source high-protein diet gut microbiota,
2018/11/16
Background: Although high-protein diets (HPDs) are frequently consumed for body-weight control, little is known about the consequences for gut microbiota composition and metabolic activity and for lar...
Intake of potassium- and magnesium-enriched salt improves functional outcome after stroke: a randomized, multicenter, double-blind controlled trial
stroke potassium magnesium enriched salt neurologic performance
2018/11/20
Background: Stroke is one of the leading causes of mortality and neurologic deficits. Management measures to improve neurologic outcomes are in great need. Our previous intervention trial in elderly s...
Probiotics (Lactobacillus gasseri KS-13, Bifidobacterium bifidum G9-1, and Bifidobacterium longum MM-2) improve rhinoconjunctivitis-specific quality of life in individuals with seasonal allergies: a double-blind, placebo-controlled, randomized trial
healthy adults probiotics seasonal allergies allergic rhinitis quality of life Lactobacillus gasseri Bifidobacterium bifidum Bifidobacterium longum
2018/11/13
Background: Rhinoconjunctivitis-specific quality of life is often reduced during seasonal allergies. The Mini Rhinoconjunctivitis Quality of Life Questionnaire (MRQLQ) is a validated tool used to meas...
Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial
α-carboxyethyl hydroxychromanol α-CEHC α-carboxymethylbutyl
2018/11/13
Background: Vitamin E supplementation improves liver histology in patients with nonalcoholic steatohepatitis, which is a manifestation of the metabolic syndrome (MetS). We reported previously that α-t...
A micronutrient-fortified young-child formula improves the iron and vitamin D status of healthy young European children: a randomized, double-blind controlled trial
iron deficiency vitamin D deficiency cow milk young-child formula vitamin D supplements micronutrient fortification young children
2018/11/12
Background: Iron deficiency (ID) and vitamin D deficiency (VDD) are common among young European children because of low dietary intakes and low compliance to vitamin D supplementation policies. Milk i...
Methylxanthines enhance the effects of cocoa flavanols on cardiovascular function: randomized, double-masked controlled studies
cocoa flavanols methylxanthines cardiovascular function interaction,
2018/11/12
Background: Cocoa flavanol intake, especially that of (−)-epicatechin, has been linked to beneficial effects on human cardiovascular function. However, cocoa also contains the methylxanthines th...
Effects of wheat-flour biscuits fortified with iron and EDTA, alone and in combination, on blood lead concentration, iron status, and cognition in children: a double-blind randomized controlled trial
NaFeEDTA cognition fortification iron lead
2018/12/18
Background: Lead is a common neurotoxicant and its absorption may be increased in iron deficiency (ID). Thus, iron fortification to prevent ID in populations is a promising lead mitigation strategy. T...
Estimation of the dietary requirement for vitamin D in adolescents aged 14–18 y: a dose-response, double-blind, randomized placebo-controlled trial
adolescents dose-response randomized controlled trial recommendations requirements vitamin D
2018/12/18
Background: Adolescents are a population group at high risk of low vitamin D status, yet the evidence base for establishing dietary vitamin D requirements remains weak.
Long-term magnesium supplementation improves arterial stiffness in overweight and obese adults: results of a randomized, double-blind, placebo-controlled intervention trial
magnesium, intervention study, arterial stiffness, pulse wave velocity, blood pressure
2018/11/29
Background: Epidemiologic studies have suggested a protective effect of magnesium intake on cardiovascular disease risk. However, intervention trials of magnesium supplementation on blood pressure and...
Acute benefits of the microbial-derived isoflavone metabolite equol on arterial stiffness in men prospectively recruited according to equol producer phenotype: a double-blind randomized controlled trial
CVD risk isoflavone flavonoids vascular function equol producer phenotype arterial stiffness
2018/11/28
Background: There is much speculation with regard to the potential cardioprotective benefits of equol, a microbial-derived metabolite of the isoflavone daidzein, which is produced in the large intesti...
Effect of zinc supplementation on serum zinc concentration and T cell proliferation in nursing home elderly: a randomized, double-blind, placebo-controlled trial
T cell proliferation nursing home elderly serum zinc concentration zinc gluconate zinc supplementation
2018/11/28
Background: Zinc is essential for the regulation of immune response. T cell function declines with age. Zinc supplementation has the potential to improve the serum zinc concentrations and immunity of ...
Dietary plant stanol ester consumption improves immune function in asthma patients: results of a randomized, double-blind clinical trial
asthma IgE immune function plant stanol esters vaccination response
2018/11/27
Background: In vitro and ex vivo studies have suggested that plant sterols and stanols can shift the T helper (Th) 1/Th2 balance toward a Th1-type immune response, which may be beneficial in Th2-domin...
Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study
Recovery, BCAA Muscle damage Resistance training
2015/7/23
It is well documented that exercise-induced muscle damage (EIMD) decreases muscle function and
causes soreness and discomfort. Branched-chain amino acid (BCAA) supplementation has been shown to incre...
The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55–92 Years): a double-blind randomized study
neuromuscular fatigue beta-alanine
2015/7/14
Ageing is associated with a significant reduction in skeletal muscle carnosine which
has been linked with a reduction in the buffering capacity of muscle and in theory, may increase the
rate of fati...