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In Down syndrome cells, genome-wide disruptions mimic a senescence-like state（图）
唐氏综合症 细胞生物学 全基因组 破坏模仿 衰老样状态
2023/6/6
In Down syndrome, the third copy of chromosome 21 causes a reorganization of the 3D configuration of the entire genome in a key cell type of the developing brain, a new study shows. The resulting disr...
Metabolic syndrome increases dietary α-tocopherol requirements as assessed using urinary and plasma vitamin E catabolites: a double-blind, crossover clinical trial
α-carboxyethyl hydroxychromanol α-CEHC α-carboxymethylbutyl
2018/11/13
Background: Vitamin E supplementation improves liver histology in patients with nonalcoholic steatohepatitis, which is a manifestation of the metabolic syndrome (MetS). We reported previously that α-t...
Visceral adiposity and metabolic syndrome after very high–fat and low-fat isocaloric diets: a randomized controlled trial
Nutritional status dietary intake body composition
2018/11/12
Background: Different aspects of dietary pattern, including macronutrient and food profiles, may affect visceral fat mass and metabolic syndrome.
Objective: We hypothesized that consuming energy prim...
High intake of regular-fat cheese compared with reduced-fat cheese does not affect LDL cholesterol or risk markers of the metabolic syndrome: a randomized controlled trial
saturated fat dairy triglycerides insulin glucose blood lipids
2018/12/14
Background: Regular-fat cheese contains a high amount of saturated fat. Therefore, dietary guidelines in many countries recommend the consumption of reduced-fat cheese as opposed to regular-fat cheese...
High intake of regular-fat cheese compared with reduced-fat cheese does not affect LDL cholesterol or risk markers of the metabolic syndrome: a randomized controlled trial
saturated fat dairy triglycerides insulin glucose blood lipids
2018/12/18
Background: Regular-fat cheese contains a high amount of saturated fat. Therefore, dietary guidelines in many countries recommend the consumption of reduced-fat cheese as opposed to regular-fat cheese...
Bats in Asia found to have resistance to white-nose syndrome fungus
Asia white-nose syndrome fungus
2016/3/21
As the deadly bat disease called white-nose syndrome continues to spread across North America, scientists are studying bats in China to understand how they are able to survive infections with the same...
Role of Adenosine A1 Receptors in Native Coronary Atherosclerosis, In-stent Stenosis, and Coronary Blood Flow Regulation in Metabolic Syndrome and Exercise
Aldosterone Coronary heart disease Exercise
2015/5/22
Adenosine is widely thought to elicit coronary vasodilation and attenuate smooth muscle cell (SMC) proliferation, thereby providing cardioprotection. We cloned the porcine adenosine A1 receptor (A1R) ...
Diet-induced dyslipidemia drives store-operated Ca2+ entry, Ca2+ dysregulation, non-alcoholic steatohepatitis, and coronary atherogenesis in metabolic syndrome
Coronary heart disease -- Risk factors Fatty liver Atherosclerosis
2015/5/22
Risk of coronary artery disease (CAD), the leading cause of death, greatly increases in metabolic syndrome. Metabolic syndrome (MetS; obesity, insulin resistance, glucose intolerance, dyslipidemia, an...
Role of Voltage-Dependent K+ and Ca2+ Channels in Coronary Electromechanical Coupling: Effects of Metabolic Syndrome
blood flow obesity metabolic syndrome
2015/5/22
Regulation of coronary blood flow is a highly dynamic process that maintains the delicate balance between oxygen delivery and metabolism in order to preserve cardiac function. Evidence to date support...
Effect of coronary perivascular adipose tissue on vascular smooth muscle function in metabolic syndrome
perivascular adipose coronary disease obesity vasoconstriction
2015/5/22
Obesity increases cardiovascular disease risk and is associated with factors of the “metabolic syndrome” (MetS), a disorder including hypertension, hypercholesterolemia and/or impaired glucose toleran...
The Pyrethroid Deltamethrin, Which Causes Choreoathetosis with Salivation (CS-Syndrome), Enhances Calcium Ion Influx via Phosphorylated CaV2.2 expresssed in Xenopus laevis oocytes
deltamethrin CaV2.2 PMA
2014/12/12
Pyrethroids are insecticides used since the 1970s. They are favored for their low mammalian toxicity, improved environmental stability and insecticidal potency. Voltage-gated sodium channels (VGSCs) a...
The action of T- and CS -syndrome pyrethroids on voltage-sensitive calcium channels in rat brain
Nerve terminals deltamethrin chrysanthemum ester calcium influx and neurotransmitter release fluorescence assay calcium influx of deltamethrin stimulation
2014/12/11
Isolated presynaptic nerve terminals (synaptosomes) prepared from rat brain were used to evaluate the action of a classic T-syndrome (cismethrin) and CS-syndrome (deltamethrin) pyrethroid on voltage-s...
Healthy Nordic diet downregulates the expression of genes involved in inflammation in subcutaneous adipose tissue in individuals with features of the metabolic syndrome
Nordic diet adipose tissue obesity polyunsaturated fatty acids transcriptome
2018/12/20
Background: Previously, a healthy Nordic diet (ND) has been shown to have beneficial health effects close to those of Mediterranean diets.
An Integrated Epidemiological and Economic Analysis of Vaccination against Highly Pathogenic Porcine Reproductive and Respiratory Syndrome (PRRS) in Thua Thien Hue Province, Vietnam
Susceptible-infectious-recovered Model Porcine Reproductive and Respiratory Syndrome Vietnam
2016/5/17
The purposes of this study are to assess pig farmers’ preference for highly pathogenic porcine reproductive and respiratory syndrome (PRRS) vaccine, and estimate the cost and benefit of PRRS vaccinati...
Association between Serum Vitamin D Status and Metabolic Syndrome in Korean Young Men
VITAMIN D BODY FATNESS CARDIORESPIRATORY FITNESS METABOLIC RISK FACTORS
2017/5/18
This study examined the relations of serum vitamin D levels to body fatness, cardiorespiratory fitness (CRF), and metabolic risk factors in young adults in Korea.