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Regulation of p53 by Mdm4 and ovarian hormones in mouse mammary glands
P53 protein genome cell cycle DNA cell apoptosis cell growth breast cancer
2014/12/11
p53 protein is considered a major player in maintaining the genomic integrity. It regulates cell cycle, recognizes damaged DNA, and promotes apoptosis of cells that are defective or developmentally pr...
Hormones, growth factors, and the regulation of tumor suppressor pathways involved in parity -induced protection of breast cancer
Women with breast cancer cases diagnosis and reproduction exogenous hormones ionizing radiation genetic factors
2014/12/11
Despite current advances in understanding breast cancer, in 2007 an estimated 178,480 new cases were diagnosed in female patients in the United States, and an estimated 40,640 deaths will occur due to...
The role of ovarian hormones in p53-mediated resistance to mammary tumorigenesis
Pregnant breast cancer rodents estrogen and progestogen therapy breast cancer the incidence of a disease
2014/12/11
A full term pregnancy reduces breast cancer by up to 50%. In rodents, pregnancy or treatment with estrogen and progesterone to mimic pregnancy reduces mammary tumor incidence. The molecular mechanisms...