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内蒙古大学“省部共建草原家畜生殖调控与繁育国家重点实验室”、生命科学学院“蒙古高原动物遗传资源研究中心”包斯琴教授带领的研究团队,2020年2月11日在《Cell》子刊《Stem Cell Reports》(中科院JCR期刊分类1区Top杂志;3年平均影响因子IF=6.458)上发表新型干细胞相关研究论文“Activin A and BMP4 Signaling Expands Potency o...
不育症给个人、家庭和社会带来严重困扰。男性不育约占人类不育病例的50%,由多种遗传和表观遗传变异所致,主要表现为生殖细胞缺失以及减数分裂启动、完成和单倍体发育异常。长期以来由于缺少精原细胞干细胞的体外培养、基因修饰以及分化模型,人类对精子发生以及男性不育的机理研究进展缓慢。
The present study identified the favorable conditions for isolation, enrichment and in vitro culture of highly purified, undifferentiated pig spermatogonial stem cell (SSC) lines that proliferate for ...
2015年8月6日,Cell Stem Cell杂志以封面文章形式刊登了北京大学生命科学学院邓宏魁与柴真课题组取得的一项重要研究成果:使用小分子化合物直接诱导小鼠成纤维细胞重编程获得功能神经元。该杂志同期还发表了中国科学院上海生命科学研究所的另一项相关发现,并配发了对这两项工作的评论文章。
Embryonic stem cells (ESCs) have been used as a powerful tool for research including gene manipulated animal models and the study of developmental gene regulation. Among the critical regulatory factor...
Capsaicin is a major constituent of hot chili peppers that influences lipid metabolism in animals. In this study, we explored the effects of capsaicin on adipogenic differentiation of bovine bone marr...
Mesenchymal stem cells (MSCs) are often known to have a therapeutic potential in the cell-mediated repair for fatal or incurable diseases. In this study, canine umbilical cord MSCs (cUC-MSCs) were iso...
Parthenogenetic embryonic stem (pES) cells could provide a valuable model for research into genomic imprinting and X-linked diseases. In this study, pES cell lines were established from oocytes of hyb...
Large quantities of high-quality recipient oocytes with uniform cytoplasm are needed for research in the promising field of somatic cell nuclear transfer (SCNT) and embryonic stem cell research. In ca...
Alfalfa (Medicago sativa L) is a high-quality forage for ruminants and the main stem is the dominant morphological component contributing to the forage nutritive value in mature alfalfa forage. Sheari...
This study was designed to simplify a cryopreservation program for embryonic stem cells (ESCs) by selection of cooling method and cryoprotectant. Commercially available mouse E14 embryonic stem cells ...
Porcine embryonic stem (ES) cells have a great potential as tools for transgenic animal production and studies of regulation of differentiation genes. Although several studies showed successful deriva...
These experiments were carried out to optimize the parameters of electrical activation, methods of parthenogenetic activation and embryo culture in vitro and meanwhile to isolate embryonic stem cells-...
The spermatogonial stem cell (SSCs) is unique in that it is the only cell in the adult male that can contribute genes to a subsequent generation. Permanent modification of the germ cell line may be re...
The objective of this study was to generate transgenic mice expressing human resistin gene by using the tetraploid- embryonic stem (ES) cell complementation method. Human resistin gene was amplified f...

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