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Sugar microarray via click chemistry: molecular recognition with lectins and amyloid β(1–42)
self-assembled monolayer saccharide microarray
2010/1/19
Sugar microarrays were fabricated on various substrates via click chemistry. Acetylene-terminated substrates were prepared by forming self-assembled monolayers (SAMs) on a gold substrate with alkyl-di...
Inhibition of Alzheimer amyloid aggregation by polyvalent trehalose
glycopolymer amyloid multivalent effect amphiphilicity
2010/10/12
A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils
from the amyloid peptide (1–42) (A ), as evaluated by thioflavin T assay and atomic force
microscopy. Glyco...