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DHA-rich n–3 fatty acid supplementation decreases DNA methylation in blood leukocytes: the OmegAD study
fish oil DHA EPA DNA methylation LINE-1 Alzheimer disease
2018/11/20
Background: Dietary fish oils, rich in long-chain n–3 (ω-3) fatty acids (FAs) [e.g., docosahexaenoic acid (DHA, 22:6n–3) and eicosapentaenoic acid (EPA, 20:5n–3)], modulate inflammatory reactions thro...
Interaction of methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium
DNA methylation epidemiology fatty acids genetic variants plasma lipids
2018/11/28
Background: DNA methylation is influenced by diet and single nucleotide polymorphisms (SNPs), and methylation modulates gene expression.
Does DNA Methylation Plays a Critical Role in Osteoblastic Differentiation of Mesenchymal Stem Cells (MSCs)?
Mesenchymal Stromal Cells Cell Differentiation Osteoblastic
2015/10/8
Mesenchymal stem cells (MSCs) are characterized by ability to differentiate into several cell types and self-renewability. These stem cells have a limited capacity in cell lineage differentiation incl...
Aberrant methylation of Glutathione Stransferase P1 and E-cadherin in invasive ductal breast carcinoma and fibroadenoma
E-cadherin Breast invasive ductal carcinoma Fibroadenoma
2012/7/13
Objective To investigate the hypermethylation status of glutathione transferase P1(GSTP1) and E-cadherin (ECAD), TSGs (tumor suppressor genes) in our breast cancer samples and explore their correlatio...
Differential methylation in steroid 5 alpha-reductase isozyme genes in epididymis, testis, and liver of the adult rat
Gene methylation gene expression androgens dihydrotestosterone eukaryotic adenine methylation
2009/2/17
DNA methylation has been largely involved in the regulation of tissue-specific gene expression. The aim of the study was to determine the methylation pattern of steroid 5 alpha-reductase genes 1 and 2...
Response to Molecular Barr Bodies：Methylation-Specific PCR of the Human X-Linked Gene FMR-1 for Diagnosis of Klinefelter Syndrome
Molecular Barr Bodies Methylation-Specific PCR Human X-Linked Gene FMR-1 Diagnosis Klinefelter Syndrome
2008/12/19
We appreciate the comments made concerning our article, "Clinical and Diagnostic Features of Patients With Suspected Klinefelter Syndrome." As we repeatedly stated in our paper, we use the Barr body a...
Molecular Barr Bodies：Methylation-Specific PCR of the Human X-Linked Gene FMR-1 for Diagnosis of Klinefelter Syndrome
Molecular Barr Bodies Methylation-Specific PCR Human X-Linked Gene FMR-1 Diagnosis Klinefelter Syndrome
2008/12/19
Kamische et al (2003) should be congratulated for their thorough and informative article on Klinefelter syndrome, published in the January-February 2003 issue of the Journal of Andrology. However, w...
Genomic DNA methylation decreases in response to moderate folate depletion in elderly women
DNA methylation genomic DNA folate homocysteine humans elderly women
2016/6/8
Background: Methylation of genomic DNA is dependent on an
adequate supply of folate coenzymes. Previous data support the
hypothesis that abnormal DNA methylation plays an integral
role in carcinoge...
Folate, DNA methylation, and gene expression: factors of nature and nurture
nature and nurture nature and nurture
2016/6/8
Folate provides the one-carbon units required for purine and
thymidylate syntheses and for methylation of a wide variety of
essential biological substances, including phospholipids, proteins,
DNA, ...