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山东大学医学院医学遗传学课件（七年制） DNA polymorphisms。
The Association Analysis between ACE and ACTN3 Genes Polymorphisms and Endurance Capacity in Young Cross-Country Skiers:Longitudinal Study
Genes polymorphisms endurance capacity skiing longitudinal study
2016/7/7
Endurance performance depends on the integration of several phenotypic traits influenced by multiple environmental and genetic factors. Objectives of the study were: (1) to examine the genotypic frequ...
Folate and homocysteine metabolism and gene polymorphisms in the etiology of Down syndrome
homocysteine metabolism gene polymorphisms
2016/6/1
One of the major advances in preventing malformations in the
past few decades had its origin in the observation by Smithells et
al (1) that multivitamin preparations are protective against neural
t...
Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight
birth weight DHA FADS long-chain PUFAs prenatal supplementation
2018/11/29
Background: Specific single nucleotide polymorphisms (SNPs) in the fatty acid desaturase (FADS) gene affect the activity and efficiency of enzymes that are responsible for the conversion of polyunsatu...
Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women
DMGDH polymorphisms pregnancy selenium status SEPP1
2018/11/23
Background: Low selenium status in pregnancy has been associated with a number of adverse conditions. In nonpregnant populations, the selenium status or response to supplementation has been associated...
CORRELATING IRINOTECAN AND CAPECITABINE TREATMENT FOR COLORECTAL CANCER TO GENE EXPRESSION, POLYMORPHISMS, AND CLINICAL OUTCOMES
Irinotecan CPT-11 Capecitabine
2015/5/25
Colorectal cancer is the third most common type of cancer and the third most common cause of cancer-related mortality. There are three types of treatment available to patients, either individually or ...
Single-Nucleotide Polymorphisms Within MicroRNAs Sequences and Their 3' UTR Target Sites May Regulate Gene Expression in Gastrointestinal Tract Cancers
MicroRNAs Gastrointestinal Neoplasms Colorectal Neoplasms Gastric Neoplasms
2015/10/13
Background: Esophageal, stomach, and colorectal cancers are commonly lethal gastrointestinal tract (GIT) neoplasms, causing almost two million deaths worldwide each year. some environmental risk facto...
Combined effect of CYP2C9 and VKORC1 polymorphisms on warfarin maintenance dose in Omani patients
CYP2C9 CYP4F2 VKORC1 Pharmacogenetics Polymorphism Omani
2013/1/30
Excepting host genetic factors, other influences on the pharmacokinetic and pharmacodynamic behavior of warfarin are subject to variations during the treatment despite attempts to stabilize the INR. I...
The Association between Sporadic Alzheimer’s Disease and the Human ABCA1 and APOE Gene Polymorphisms in Iranian Population
Alzheimer’s disease Genetic association Apolipoprotein E Polymorphism ATP-binding cassette transporter A1 Iran
2015/9/23
Background: Apolipoprotein E (APOE), which its ε4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain. ATP-binding cassette t...
Interleukin-12 and Tumor Necrosis Factor-Β Gene Polymorphisms as Genetic Susceptibility Factors for Brucellosis in Iranian Patients
Brucella Genetic polymorphisms Interleukin-12 Tumor necrosis factor-β Iran
2015/9/21
cMethods: One hundred and ninety-six patients with brucellosis and 81 healthy farmers (controls) who owned infected animals and consumed their contaminated dairy products were included in this study. ...
Heme Oxigenase 2 Gene Polymorphisms as Genetic Risk Factor in Atherosclerosis in Iranian Patients
Atherosclerosis Heme oxigenase 2 Coronary artery disease Iran
2015/9/21
Background: Heme oxygenase 2 (HMOX2) is an important antioxidative stress enzyme found in the endothelial cells of blood vessels and adventitial nerves. This enzyme in collaboration with heme oxygenas...
N-acetyltransferase 2 gene polymorphisms and susceptibility to prostate cancer: a pilot study in the Turkish population
N-Acetyltransferase 2 prostate cancer acetylator phenotype
2010/10/14
To investigate the association between the 3 most frequently observed single nucleotide polymorphisms of the NAT2 gene and the risk of developing prostate cancer in the Turkish population. Materials a...
Transferrin Polymorphisms in Childhood Malarial Anaemia in the Gabonese Children
P. falciparum malarial anaemia transferrin polymorphisms
2010/12/10
Severe malarial anaemia (SMA) is one of the most outstanding complications of malaria in African children. It is often associated with iron deficiency, but explorations of soluble transferrin revealed...
Association between Endothelial Selectin (E-Selectin) Gene Polymorphisms and E-Selectin Level with Visceral Leishmaniais, in an ARMS-PCR Based Study
Soluble E-selectin Gene Polymorphism Visceral Leishmaniasis Human ARMS-PCR Ser128Arg 554Leu/Phe
2009/12/18
Background: In the visceral leishmaniasis (VL), parasites reside in reticuluendothelial system, mainly in macrophages. Endothelial Selectin (E-selectin) might play an important role in leukocyte-endot...
Gene Polymorphisms and Chemotherapy in Non-small Cell Lung Cancer
Lung neoplasms Genetic polymorphism Drug therapy
2013/12/10
The phamacogenetics is being used to predict whether the selected chemotherapy will be really effective and tolerable to the patient. Irinotecan, oxidized by CYP3A4 to produce inactive compounds, is u...