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The brief of this issue of Cancer Forum is to review information available since the 2005 publication of the National Health and Medical Research Council relating to risk management of individuals wit...
Family history of colorectal cancer is a well-established and consistently strong risk factor for this disease. However, simply counting the number of affected relatives is an imprecise measure of col...
Microarray-based transcript profiling is a technique used to measure the steady-state levels of gene expression on a genome-wide scale in a cell or tissue. The technology essentially involves making a...
This dissertation presents a body of research that attempts to tackle the ‘overfittingproblem for gene signature and biomarker development in two different aspects (mechanistically and computational...
In this study, we compared gene transfer efficiency and host response to ultrasound-assisted, nonviral gene transfer with a conventional plasmid and a minicircle vector in the submandibular salivary g...
Examining a team’s performance from a physical point of view their momentum might indicate unexpected turning points in defeat or success. Physicists describe this value as to require some effort to b...
Use of microarrays to analyze drug responses has mainly been restricted to comparing treated versus untreated samples at a few time points. In order to decipher the complex expression interactions and...
Background: Glucantime® is the first- line drug for the treatment of all forms of leishmaniasis. Unfortunately, the prevalence of parasites becoming resistant to Glucantime® is increasing in s...
We have demonstrated a combined imaging system, where the physiology of biological specimens can be imaged and profiled at 10–20 frames per second whilst undergoing femtosecond laser irradiation. Indi...
New work by MIT cancer biologists shows that the interplay between two key genes that are often defective in tumors determines how cancer cells respond to chemotherapy.The findings should have an imme...
Activation of the steroidogenic machinery by peptide hormones involves a number of steps for transmitting signals from the plasma membrane to mitochondria in a spatially and temporally coordinated...
4 December 2006,Traditional multiplexed gene expression methods require well preserved, intact RNA. Such specimens are difficult to acquire in clinical practice where formalin fixation is the standard...
We investigated the influence of two methods of lumen reconstruction, assuming circular versus elliptical cross-sections and using different resolutions for the cross-section reconstructions along the...
The MC lineage seems to be far from the granulocyte lineages including basophils. CMA1-high MCs (MCTC) and CMA1-low MCs (MCT) can be regarded as differentiated MC subtypes. As such, importance of data...
Volume 1 of the AAPS Press series, Biotechnology: Pharmaceutical Aspects. Based on a 2003 AAPS workshop of the same name, Pharmaceutical Profiling in Drug Discovery for Lead Selection emphasizes the i...

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