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2017老化和老化相关疾病的机制 Keystone Symposia（2017 Keystone Symposia on Aging and Mechanisms of Aging-Related Disease）
Aging-Related Disease protein homeostasis
2017/3/7
Populations are aging rapidly worldwide, particularly in Asia, driving a strong interest in aging/longevity research. This Keystone Symposia meeting will capture the cutting-edge front of this excitin...
2016冷泉港学术会议：代谢信号机制（Cold Spring Harbor conference on Mechanisms of Metabolic Signaling）
Genetics Genomes
2017/1/19
Metabolic regulation is at the intersection of many scientific fields, ranging from basic biochemistry and molecular biology to physiology, to the study of disease pathogenesis. Currently, a major cha...
2017病毒免疫 Keystone Symposia（2017 Keystone Symposia on Viral Immunity: Mechanisms and Consequences）
Viral Immunity Mechanisms Consequences
2017/1/17
The meeting will begin on Sunday, February 19 with registration from 16:00 to 20:00 and a welcome mixer from 18:00 to 20:00. Conference events conclude on Thursday, February 23 with a closing plenary ...
Mechanisms of translational regulation in the pancreatic β cell stress response
Diabetes Islet ER stress Pdx1
2015/5/22
The islet beta cell is unique in its ability to synthesize and secrete insulin for use in the body. A number of factors including proinflammatory cytokines, free fatty acids, and islet amyloid are kno...
Mechanisms of hexosamine-induced cholesterol accumulation and therapeutic actions of chromium
cholesterol accumulation therapeutic actions
2015/5/22
Excess caloric intake and/or obesity currently remain the largest predisposing risk factors for the development of type 2 diabetes. Discerning the cellular and molecular mechanisms responsible and ame...
Morphological Assessment of Basic Multicellular Unit Resorption Parameters in Dogs Shows Additional Mechanisms of Bisphosphonate Effects on Bone
basic multicellular unit alendronate
2014/12/4
Bisphosphonates (BPs) slow bone loss by reducing initiation of new basic multicellular units (BMUs). Whether or not BPs simply prevent osteoclasts from initiating new BMUs that resorb bone or also red...
Immunological tolerance refers to a reduction or complete inhibition of the ability of an individual to mount a specific immune response upon immunization.
Innate Immune Mechanisms: Nonself Recognition
固有免疫机制：非己的识别 Innate Immune Mechanisms: Nonself Recognition
2014/6/24
The innate immune system contains a range of cell-bound and soluble proteins which eliminate pathogens by recognizing unique molecular patterns expressed by microorganisms, but not by host cells. Alte...
Introduction of an exogenous antigen into the fetus at the time of repertoire maturation renders the host’s immune system tolerant to that antigen. This view stems from a historical observation of non...
Pathological Mechanisms and Clinical Features of Eosinophilic Chronic Rhinosinusitis in the Japanese Population
endoscopic sinus surgery eosinophilic chronic rhinosinusitis glucocorticoids Toll-like receptor transcription factors
2010/11/12
The overall pathological view of paranasal sinus inflammation in the Japanese population has profoundly changed in recent years. Eosinophilic chronic rhinosinusitis (ECRS) is a clinical entity of intr...
Immune Mechanisms in Drug Allergy
autologous cytotoxicity drug hypersensitivity epidermal HLA immunologic T-lymphocytes toxic
2010/11/18
In the last decade several teams of researchers obtained in vitro drug-specific human T-cell clones, in a variety of clinical types of drug eruptions. These clones were produced from blood or skin mon...
Mechanisms of eosinophilic inflammation in the mucosa of the nasal cavity and paranasal sinus
allergic rhinitis eosinophil eotaxin
2010/11/25
More than one mechanism contributes to persistent increases in eosinophils in the nasal cavity and paranasal sinus. The levels of eotaxin in lavage samples obtained after antigen challenge showed stro...
Mechanisms involved in human eosinophil chemotaxis induced by the newly cloned C-C chemokine eotaxin
calcium chemotaxis eosinophil eotaxin signaling
2010/11/29
The present study was performed in order to investigate the mechanism(s) involved in eotaxin-induced normal human eosinophil chemotaxis using a 48-well microchemotaxis chamber assay. Eotaxin, at a wid...