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The Regulatory Role Of Matrix Metalloproteinases In T Cell Activation
T cell activation MMP9 Matrix Metalloproteinases
2015/5/25
Introduction: Matrix metalloproteinases (MMPs) are known for their role in extracellular matrix remodeling, but their role in regulating intracellular immune cell function is unknown. We reported that...
CONTRIBUTION OF RANKL REGULATION TO BONE RESORPTION INDUCED BY PTH RECEPTOR ACTIVATION IN OSTEOCYTES
RANKL REGULATION CONTRIBUTION
2015/5/21
PTH increases osteoclasts by upregulating RANKL in cells of the osteoblastic lineage, but the precise differentiation stage of the PTH target cell remains undefined. Recent findings demonstrate that P...
Applying Surface Plasmon Resonance to Monitor the IgE-Mediated Activation of Human Basophils
basophil biosensor histamine release IgE surface plasmon resonance
2010/11/17
When basophils were sensitized with antigen specific IgE, they immediately caused the increase of resonance angle (AR) in response to either anti-IgE antibody or corresponding antigens, even when they...
Non-specific activation of human eosinophil functional responses by vasoactive intestinal peptide
allergic inflammation eosinophil functional response signal transduction vasoactive intestinal peptide
2010/11/25
Eosinophils and neuropeptides are thought to play effector roles in allergic diseases, such as rhinitis; however, little is known about the biological effects of neuromediators, especially vasoactive ...
Human mast cell activation through Fc receptors and Toll-like receptors
adaptive immunity FcεRI FcγRI GeneChip innate immunity mast cell Toll-like receptor 4
2010/11/22
Mast cells express high-affinity IgE receptors (FcεRI) on their surface and can be activated to secrete a variety of biologically active mediators by cross-linking of receptor-bound IgE. Recent studie...
Role of adhesion molecules in eosinophil activation: A comparative study on the effect of adhesion molecules on eosinophil survival
adhesion molecule β integrin eosinophil fibronectin survival
2010/11/22
Background: Adhesion molecules participate in an important part of inflammatory process in relation to the accumulation of inflammatory cells, such as eosinophils. The expression of adhesion molecules...
Platelet-activating Factor or Complement 5a Causes Distinct Activation Profiles in Human Eosinophil and Neutrophil Functions
adhesion complement 5a eosinophils neutrophils platelet-activating factor superoxide anion β2 integrin
2010/11/19
Eosinophils and neutrophils showed different activation profiles with stimulation of PAF or C5a on HSA-coated surfaces. In eosinophils the intensity of cellular adhesion and O2- release paralleled the...
Role of signaling lymphocytic activation molecule in T helper cell responses
allergy interferon-γ signaling lymphocytic activation molecule (CDw150) T cell activation Th2 responses
2010/11/29
Signaling lymphocytic activation molecule (SLAM; CDw150) is a 70 kDa glycoprotein. Signaling lymphocytic activation molecule is constitutively expressed on memory T cells, CD56+ T cells, a subset of T...