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日前，生命学院刘木根教授团队在造血干细胞发育研究中取得重要进展。2月21日，国际血液学权威期刊Blood杂志以封面文章发表该团队研究论文“BCAS2 is essential for hematopoietic stem and progenitor cell maintenance during zebrafish embryogenesis”（Blood. 2019;133(8):805-81...
Smart molecules trigger white blood cells to become better cancer-eating machines
Smart molecules trigger blood cells cancer-eating machines
2017/10/25
A team of researchers has engineered smart protein molecules that can reprogram white blood cells to ignore a self-defense signaling mechanism that cancer cells use to survive and spread in the body. ...
Artificial Blood Vessels Mimic Rare Accelerated Aging Disease（图）
Artificial Blood Vessels Mimic Accelerated Aging Disease
2017/9/5
Biomedical engineers have grown miniature human blood vessels that exhibit many of the symptoms and drug reactions associated with Hutchinson-Gilford Progeria Syndrome—an extremely rare genetic diseas...
Study:Changing the environment within bone marrow alters blood cell development
Changing the environment bone marrow blood cell development
2017/3/14
Researchers at the University of Illinois report they can alter blood cell development through the use of biomaterials designed to mimic characteristics of the bone marrow.The findings, reported in th...
BLOOD：髓系细胞向白细胞分化的新方法
BLOOD 髓系细胞 白细胞分化 新方法
2012/11/9
伊利诺依大学王霏教授和他的同事李栋（生物谷专访李栋博士）等人建立了一个新的方法来研究造血干细胞向成熟白细胞分化，而后者对于机体防御外界感染或者损伤的免疫系统非常重要。这个技术为我们提供了一个新的视觉来研究髓系细胞分化的分子机制，有助于我们对于髓系细胞疾病如白血病的认识和处理。该项成果发表于10 月18 日的BLOOD上。
The Effect Of 8 Day Storage At 4˚C On Total Nucleated Cell Count,Cell Viability, And Granulocyte-Macrophage Colony Forming Unit Of Mobilized Peripheral Blood
peripheral blood progenitor cell refrigeration GM-CFU
2009/12/24
Background: Hematopoietic stem cell (HSC) transplantation has brought the possibility of the use of high dose chemotherapy in the treatment of malignant hematopoietic diseases. Short-term HSC preserva...
Comparative Cytotoxicity of Fludarabine in Human Peripheral Blood Mononuclear Cells and in the Promyelocytic Leukemia Cell Line (HL60)
HL60 MTT assay fludarabine cytotoxicity differentiation
2009/6/23
Fludarabine is an inhibitor of DNA/RNA synthesis with antitumor activity on lymphoproliferative malignancies. We investigated the dose-dependent cytotoxic effects of the drug on human peripheral blood...
The Effect of Glutathione S-transferase M1 Genotype on Benzo[a]pyrene-Induced Sister Chromatid Exchanges and Chromosomal Aberrations in Peripheral Blood Lymphocytes
Department of Medical Biology,Cerrahpaş a Faculty of Medicine,University of İ stanbul,İ stanbul-Turkey
2009/6/23
Sister chromatid exchange (SCE) and chromosomal aberration (CA) in peripheral lymphocytes have been widely used in assessing exposure to mutagens and carcinogens. One of the extensively studied genoto...
Direct flowcytometric analysis of eosinophils using a whole blood staining technique
EG2 eosinophils flow cytometry whole blood
2010/11/25
The findings show that intra- and extracellular properties of eosinophils can be analyzed with whole blood using PBQ fixation and OG treatment at a concentration of 7.4 mg/mL. Direct flowcytometric an...
Concentrations of eosinophil-derived neurotoxin in the blood and urine of patients with allergic diseases
allergic rhinitis atopic dermatitis bronchial asthma eosinophil-derived neurotoxin eosinophil
2010/11/24
The median concentrations of EDN in blood and urine and the number of eosinophils in peripheral blood from patients with active symptoms were all significantly higher compared with values obtained whe...
The Effect of Suplatast Tosilate on TARC Production in Peripheral Blood Mononuclear Cells and TARC Plasma Levels
allergic rhinitis chemokines suplatast tosilate TARC
2010/11/22
Suplatast tosilate significantly reduced TARC production by PBMCs. TARC mRNA was also suppressed in a concentration dependent manner. However, suplatast tosilate did not inhibit the expression of CCR-...
Suplatast Tosilate Inhibits Human Mast Cell Development from Cord Blood Progenitors
cord blood progenitors human mast cells stem cell factor suplatast tosilate
2010/11/19
Background: Localized mast cell accumulation has been reported in a number of human diseases. Suplatast tosilate has been reported to inhibit IL-3-dependent murine mast cell development, and therefore...
Bronchial and nasal responsiveness in atopic asthma and allergic rhinitis patients: Relationship of local responsiveness to cytokine production by peripheral blood mononuclear cells
allergic rhinitis atopy bronchial asthma bronchial responsiveness interleukin-4 interleukin-5 nasal responsiveness
2010/11/29
To investigate the relationship between local responsiveness and allergic symptoms, bronchial and nasal responsiveness were measured in the following four groups of subjects: (i) bronchial asthma pati...